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Higher Vulnerability of Menadione-Exposed Cortical Astrocytes of Glutaryl-CoA Dehydrogenase Deficient Mice to Oxidative Stress, Mitochondrial Dysfunction, and Cell Death: Implications for the Neurodegeneration in Glutaric Aciduria Type I.
Rodrigues MDN, Seminotti B, Zanatta Â, de Mello Gonçalves A, Bellaver B, Amaral AU, Quincozes-Santos A, Goodman SI, Woontner M, Souza DO, Wajner M. Rodrigues MDN, et al. Among authors: zanatta a. Mol Neurobiol. 2017 Aug;54(6):4795-4805. doi: 10.1007/s12035-016-0023-z. Epub 2016 Aug 10. Mol Neurobiol. 2017. PMID: 27510504
Evidence that folic acid deficiency is a major determinant of hyperhomocysteinemia in Parkinson's disease.
dos Santos EF, Busanello EN, Miglioranza A, Zanatta A, Barchak AG, Vargas CR, Saute J, Rosa C, Carrion MJ, Camargo D, Dalbem A, da Costa JC, de Sousa Miguel SR, de Mello Rieder CR, Wajner M. dos Santos EF, et al. Among authors: zanatta a. Metab Brain Dis. 2009 Jun;24(2):257-69. doi: 10.1007/s11011-009-9139-4. Epub 2009 Mar 18. Metab Brain Dis. 2009. PMID: 19294496
Inhibition of creatine kinase activity by lysine in rat cerebral cortex.
Tonin AM, Ferreira GC, Schuck PF, Viegas CM, Zanatta A, Leipnitz G, Seminotti B, Duvall Wannmacher CM, Wajner M. Tonin AM, et al. Among authors: zanatta a. Metab Brain Dis. 2009 Jun;24(2):349-60. doi: 10.1007/s11011-009-9131-z. Epub 2009 Apr 16. Metab Brain Dis. 2009. PMID: 19370404
Striatum is more vulnerable to oxidative damage induced by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as compared to liver.
Leipnitz G, Seminotti B, Fernandes CG, Amaral AU, Beskow AP, da Silva Lde B, Zanatta A, Ribeiro CA, Vargas CR, Wajner M. Leipnitz G, et al. Among authors: zanatta a. Int J Dev Neurosci. 2009 Jun;27(4):351-6. doi: 10.1016/j.ijdevneu.2009.03.001. Epub 2009 Mar 13. Int J Dev Neurosci. 2009. PMID: 19460629
197 results