Zhi L - Search Results

1

Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD-6972 in healthy subjects and subjects with type 2 diabetes mellitus.

Vajda EG, Logan D, Lasseter K, Armas D, Plotkin DJ, Pipkin JD, Li YX, Zhou R, Klein D, Wei X, Dilzer S, Zhi L, Marschke KB. Vajda EG, et al. Among authors: zhi l. Diabetes Obes Metab. 2017 Jan;19(1):24-32. doi: 10.1111/dom.12752. Epub 2016 Aug 31. Diabetes Obes Metab. 2017. PMID: 27501510 Free PMC article.

2

Efficacy and Safety of the Glucagon Receptor Antagonist RVT-1502 in Type 2 Diabetes Uncontrolled on Metformin Monotherapy: A 12-Week Dose-Ranging Study.

Pettus JH, D'Alessio D, Frias JP, Vajda EG, Pipkin JD, Rosenstock J, Williamson G, Zangmeister MA, Zhi L, Marschke KB. Pettus JH, et al. Among authors: zhi l. Diabetes Care. 2020 Jan;43(1):161-168. doi: 10.2337/dc19-1328. Epub 2019 Nov 6. Diabetes Care. 2020. PMID: 31694861 Clinical Trial.

3

Combination treatment with a selective androgen receptor modulator q(SARM) and a bisphosphonate has additive effects in osteopenic female rats.

Vajda EG, Hogue A, Griffiths KN, Chang WY, Burnett K, Chen Y, Marschke K, Mais DE, Pedram B, Shen Y, van Oeveren A, Zhi L, López FJ, Meglasson MD. Vajda EG, et al. Among authors: zhi l. J Bone Miner Res. 2009 Feb;24(2):231-40. doi: 10.1359/jbmr.081007. J Bone Miner Res. 2009. PMID: 18847323 Free article.

4

Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators.

Martinborough E, Shen Y, Oeveren Av, Long YO, Lau TL, Marschke KB, Chang WY, López FJ, Vajda EG, Rix PJ, Viveros OH, Negro-Vilar A, Zhi L. Martinborough E, et al. Among authors: zhi l. J Med Chem. 2007 Oct 18;50(21):5049-52. doi: 10.1021/jm070231h. Epub 2007 Sep 21. J Med Chem. 2007. PMID: 17887661

5

Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile.

Miner JN, Ardecky B, Benbatoul K, Griffiths K, Larson CJ, Mais DE, Marschke K, Rosen J, Vajda E, Zhi L, Negro-Vilar A. Miner JN, et al. Among authors: zhi l. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19244-9. doi: 10.1073/pnas.0705517104. Epub 2007 Nov 21. Proc Natl Acad Sci U S A. 2007. PMID: 18032610 Free PMC article.

6

LGD-5552, an antiinflammatory glucocorticoid receptor ligand with reduced side effects, in vivo.

López FJ, Ardecky RJ, Bebo B, Benbatoul K, De Grandpre L, Liu S, Leibowitz MD, Marschke K, Rosen J, Rungta D, Viveros HO, Yen WC, Zhi L, Negro-Vilar A, Miner JN. López FJ, et al. Among authors: zhi l. Endocrinology. 2008 May;149(5):2080-9. doi: 10.1210/en.2007-1353. Epub 2008 Jan 24. Endocrinology. 2008. PMID: 18218700

7

Discovery of a novel series of nonsteroidal androgen receptor modulators: 5- or 6-oxachrysen-2-ones.

Zhao S, Shen Y, van Oeveren A, Marschke KB, Zhi L. Zhao S, et al. Among authors: zhi l. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3431-5. doi: 10.1016/j.bmcl.2008.03.085. Epub 2008 Apr 8. Bioorg Med Chem Lett. 2008. PMID: 18442912

8

A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinoline.

Pedram B, van Oeveren A, Mais DE, Marschke KB, Verbost PM, Groen MB, Zhi L. Pedram B, et al. Among authors: zhi l. J Med Chem. 2008 Jul 10;51(13):3696-9. doi: 10.1021/jm8004256. Epub 2008 Jun 14. J Med Chem. 2008. PMID: 18553958

9

Switching androgen receptor antagonists to agonists by modifying C-ring substituents on piperidino[3,2-g]quinolinone.

Zhi L, Tegley CM, Marschke KB, Jones TK. Zhi L, et al. Bioorg Med Chem Lett. 1999 Apr 5;9(7):1009-12. doi: 10.1016/s0960-894x(99)00119-5. Bioorg Med Chem Lett. 1999. PMID: 10230629

10

Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators.

Zhi L, Tegley CM, Pio B, Edwards JP, Jones TK, Marschke KB, Mais DE, Risek B, Schrader WT. Zhi L, et al. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2071-4. doi: 10.1016/s0960-894x(03)00255-5. Bioorg Med Chem Lett. 2003. PMID: 12781197

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