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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
Khare S, Nagle AS, Biggart A, Lai YH, Liang F, Davis LC, Barnes SW, Mathison CJ, Myburgh E, Gao MY, Gillespie JR, Liu X, Tan JL, Stinson M, Rivera IC, Ballard J, Yeh V, Groessl T, Federe G, Koh HX, Venable JD, Bursulaya B, Shapiro M, Mishra PK, Spraggon G, Brock A, Mottram JC, Buckner FS, Rao SP, Wen BG, Walker JR, Tuntland T, Molteni V, Glynne RJ, Supek F. Khare S, et al. Among authors: brock a. Nature. 2016 Sep 8;537(7619):229-233. doi: 10.1038/nature19339. Epub 2016 Aug 8. Nature. 2016. PMID: 27501246 Free PMC article.
Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197.
Malito E, Bursulaya B, Chen C, Lo Surdo P, Picchianti M, Balducci E, Biancucci M, Brock A, Berti F, Bottomley MJ, Nissum M, Costantino P, Rappuoli R, Spraggon G. Malito E, et al. Among authors: brock a. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5229-34. doi: 10.1073/pnas.1201964109. Epub 2012 Mar 19. Proc Natl Acad Sci U S A. 2012. PMID: 22431623 Free PMC article.
N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.
Molteni V, Li X, Nabakka J, Liang F, Wityak J, Koder A, Vargas L, Romeo R, Mitro N, Mak PA, Seidel HM, Haslam JA, Chow D, Tuntland T, Spalding TA, Brock A, Bradley M, Castrillo A, Tontonoz P, Saez E. Molteni V, et al. Among authors: brock a. J Med Chem. 2007 Aug 23;50(17):4255-9. doi: 10.1021/jm070453f. Epub 2007 Aug 1. J Med Chem. 2007. PMID: 17665897
454 results