Gearhart PJ - Search Results

1

Binding of estrogen receptors to switch sites and regulatory elements in the immunoglobulin heavy chain locus of activated B cells suggests a direct influence of estrogen on antibody expression.

Jones BG, Penkert RR, Xu B, Fan Y, Neale G, Gearhart PJ, Hurwitz JL. Jones BG, et al. Among authors: gearhart pj. Mol Immunol. 2016 Sep;77:97-102. doi: 10.1016/j.molimm.2016.07.015. Epub 2016 Aug 3. Mol Immunol. 2016. PMID: 27494228 Free PMC article.

2

Hotspots for Vitamin-Steroid-Thyroid Hormone Response Elements Within Switch Regions of Immunoglobulin Heavy Chain Loci Predict a Direct Influence of Vitamins and Hormones on B Cell Class Switch Recombination.

Hurwitz JL, Penkert RR, Xu B, Fan Y, Partridge JF, Maul RW, Gearhart PJ. Hurwitz JL, et al. Among authors: gearhart pj. Viral Immunol. 2016 Mar;29(2):132-6. doi: 10.1089/vim.2015.0104. Epub 2016 Jan 7. Viral Immunol. 2016. PMID: 26741514 Free PMC article.

3

Complex sex-biased antibody responses: estrogen receptors bind estrogen response elements centered within immunoglobulin heavy chain gene enhancers.

Jones BG, Sealy RE, Penkert RR, Surman SL, Maul RW, Neale G, Xu B, Gearhart PJ, Hurwitz JL. Jones BG, et al. Among authors: gearhart pj. Int Immunol. 2019 Mar 5;31(3):141-156. doi: 10.1093/intimm/dxy074. Int Immunol. 2019. PMID: 30407507 Free PMC article.

4

Matters of life and death: How estrogen and estrogen receptor binding to the immunoglobulin heavy chain locus may influence outcomes of infection, allergy, and autoimmune disease.

Jones BG, Penkert RR, Surman SL, Sealy RE, Pelletier S, Xu B, Neale G, Maul RW, Gearhart PJ, Hurwitz JL. Jones BG, et al. Among authors: gearhart pj. Cell Immunol. 2019 Dec;346:103996. doi: 10.1016/j.cellimm.2019.103996. Epub 2019 Oct 25. Cell Immunol. 2019. PMID: 31703914 Free PMC article. Review.

5

From Influenza Virus Infections to Lupus: Synchronous Estrogen Receptor α and RNA Polymerase II Binding Within the Immunoglobulin Heavy Chain Locus.

Jones BG, Sealy RE, Penkert RR, Surman SL, Birshtein BK, Xu B, Neale G, Maul RW, Gearhart PJ, Hurwitz JL. Jones BG, et al. Among authors: gearhart pj. Viral Immunol. 2020 May;33(4):307-315. doi: 10.1089/vim.2019.0144. Epub 2020 Feb 27. Viral Immunol. 2020. PMID: 32105583 Free PMC article.

6

Successive switching of antibody isotypes expressed within the lines of a B-cell clone.

Gearhart PJ, Hurwitz JL, Cebra JJ. Gearhart PJ, et al. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5424-8. doi: 10.1073/pnas.77.9.5424. Proc Natl Acad Sci U S A. 1980. PMID: 6776537 Free PMC article.

7

Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion.

Heltemes-Harris LM, Gearhart PJ, Ghosh P, Longo DL. Heltemes-Harris LM, et al. Among authors: gearhart pj. Mol Immunol. 2008 Mar;45(6):1799-806. doi: 10.1016/j.molimm.2007.09.020. Epub 2007 Nov 5. Mol Immunol. 2008. PMID: 17983655 Free PMC article.

8

Nucleotide excision repair in an immunoglobulin variable gene is less efficient than in a housekeeping gene.

Alrefai RH, Winter DB, Bohr VA, Gearhart PJ. Alrefai RH, et al. Among authors: gearhart pj. Mol Immunol. 2007 Apr;44(11):2800-5. doi: 10.1016/j.molimm.2007.01.018. Epub 2007 Mar 1. Mol Immunol. 2007. PMID: 17336386 Free PMC article.

9

J_H6 downstream intronic sequence is dispensable for RNA polymerase II accumulation and somatic hypermutation of the variable gene in Ramos cells.

Castiblanco DP, Norton DD, Maul RW, Gearhart PJ. Castiblanco DP, et al. Among authors: gearhart pj. Mol Immunol. 2018 May;97:101-108. doi: 10.1016/j.molimm.2018.03.031. Epub 2018 Apr 4. Mol Immunol. 2018. PMID: 29625296 Free PMC article.

10

What Targets Somatic Hypermutation to the Immunoglobulin Loci?

Heltzel JMH, Gearhart PJ. Heltzel JMH, et al. Among authors: gearhart pj. Viral Immunol. 2020 May;33(4):277-281. doi: 10.1089/vim.2019.0149. Epub 2019 Nov 26. Viral Immunol. 2020. PMID: 31770070 Free PMC article. Review.

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