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The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines.
Wildenberg ME, Koelink PJ, Diederen K, Te Velde AA, Wolfkamp SC, Nuij VJ, Peppelenbosch MP, Nobis M, Sansom OJ, Anderson KI, van der Woude CJ, D'Haens GR, van den Brink GR. Wildenberg ME, et al. Among authors: diederen k. Mucosal Immunol. 2017 Mar;10(2):352-360. doi: 10.1038/mi.2016.65. Epub 2016 Jul 20. Mucosal Immunol. 2017. PMID: 27435106 Free article.
Exclusive enteral nutrition mediates gut microbial and metabolic changes that are associated with remission in children with Crohn's disease.
Diederen K, Li JV, Donachie GE, de Meij TG, de Waart DR, Hakvoort TBM, Kindermann A, Wagner J, Auyeung V, Te Velde AA, Heinsbroek SEM, Benninga MA, Kinross J, Walker AW, de Jonge WJ, Seppen J. Diederen K, et al. Sci Rep. 2020 Nov 3;10(1):18879. doi: 10.1038/s41598-020-75306-z. Sci Rep. 2020. PMID: 33144591 Free PMC article.
70 results