Osgood S - Search Results

1

Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase.

Allen JG, Mujacic M, Frohn MJ, Pickrell AJ, Kodama P, Bagal D, San Miguel T, Sickmier EA, Osgood S, Swietlow A, Li V, Jordan JB, Kim KW, Rousseau AC, Kim YJ, Caille S, Achmatowicz M, Thiel O, Fotsch CH, Reddy P, McCarter JD. Allen JG, et al. Among authors: osgood s. ACS Chem Biol. 2016 Oct 21;11(10):2734-2743. doi: 10.1021/acschembio.6b00460. Epub 2016 Aug 11. ACS Chem Biol. 2016. PMID: 27434622

2

Telescoped Process to Manufacture 6,6,6-Trifluorofucose via Diastereoselective Transfer Hydrogenation: Scalable Access to an Inhibitor of Fucosylation Utilized in Monoclonal Antibody Production.

Achmatowicz MM, Allen JG, Bio MM, Bartberger MD, Borths CJ, Colyer JT, Crockett RD, Hwang TL, Koek JN, Osgood SA, Roberts SW, Swietlow A, Thiel OR, Caille S. Achmatowicz MM, et al. Among authors: osgood sa. J Org Chem. 2016 Jun 3;81(11):4736-43. doi: 10.1021/acs.joc.6b00646. Epub 2016 May 20. J Org Chem. 2016. PMID: 27152753

3

Mechanistic Insights into the Racemization of Fused Cyclopropyl Isoxazolines.

Quasdorf KW, Birkholz AB, Bartberger MD, Colyer J, Osgood S, Crossley K, Caille S. Quasdorf KW, et al. Among authors: osgood s. Org Lett. 2020 Mar 20;22(6):2113-2117. doi: 10.1021/acs.orglett.9b04236. Epub 2019 Dec 20. Org Lett. 2020. PMID: 31859518

4

SAR by MS: discovery of a new class of RNA-binding small molecules for the hepatitis C virus: internal ribosome entry site IIA subdomain.

Seth PP, Miyaji A, Jefferson EA, Sannes-Lowery KA, Osgood SA, Propp SS, Ranken R, Massire C, Sampath R, Ecker DJ, Swayze EE, Griffey RH. Seth PP, et al. Among authors: osgood sa. J Med Chem. 2005 Nov 17;48(23):7099-102. doi: 10.1021/jm050815o. J Med Chem. 2005. PMID: 16279767

5

New inhibitors of bacterial protein synthesis from a combinatorial library of macrocycles.

Jefferson EA, Arakawa S, Blyn LB, Miyaji A, Osgood SA, Ranken R, Risen LM, Swayze EE. Jefferson EA, et al. Among authors: osgood sa. J Med Chem. 2002 Aug 1;45(16):3430-9. doi: 10.1021/jm010437x. J Med Chem. 2002. PMID: 12139453

6

SAR by MS: a ligand based technique for drug lead discovery against structured RNA targets.

Swayze EE, Jefferson EA, Sannes-Lowery KA, Blyn LB, Risen LM, Arakawa S, Osgood SA, Hofstadler SA, Griffey RH. Swayze EE, et al. Among authors: osgood sa. J Med Chem. 2002 Aug 29;45(18):3816-9. doi: 10.1021/jm0255466. J Med Chem. 2002. PMID: 12190303

7

Antibacterial activity of quinolone-macrocycle conjugates.

Jefferson EA, Swayze EE, Osgood SA, Miyaji A, Risen LM, Blyn LB. Jefferson EA, et al. Bioorg Med Chem Lett. 2003 May 19;13(10):1635-8. doi: 10.1016/s0960-894x(03)00285-3. Bioorg Med Chem Lett. 2003. PMID: 12729630

8

Identification of 2-aminobenzimidazole dimers as antibacterial agents.

Seth PP, Jefferson EA, Risen LM, Osgood SA. Seth PP, et al. Bioorg Med Chem Lett. 2003 May 19;13(10):1669-72. doi: 10.1016/s0960-894x(03)00245-2. Bioorg Med Chem Lett. 2003. PMID: 12729638

9

Biaryl guanidine inhibitors of in vitro HCV-IRES activity.

Jefferson EA, Seth PP, Robinson DE, Winter DK, Miyaji A, Osgood SA, Swayze EE, Risen LM. Jefferson EA, et al. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5139-43. doi: 10.1016/j.bmcl.2004.07.066. Bioorg Med Chem Lett. 2004. PMID: 15380215

10

Optimizing the antibacterial activity of a lead structure discovered by "SAR by MS" technology.

Jefferson EA, Seth PP, Robinson DE, Winter DK, Miyaji A, Risen LM, Osgood SA, Bertrand M, Swayze EE. Jefferson EA, et al. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5257-61. doi: 10.1016/j.bmcl.2004.08.033. Bioorg Med Chem Lett. 2004. PMID: 15454207

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