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CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14.
Patterson BK, Seethamraju H, Dhody K, Corley MJ, Kazempour K, Lalezari J, Pang APS, Sugai C, Mahyari E, Francisco EB, Pise A, Rodrigues H, Wu HL, Webb GM, Park BS, Kelly S, Pourhassan N, Lelic A, Kdouh L, Herrera M, Hall E, Bimber BN, Plassmeyer M, Gupta R, Alpan O, O'Halloran JA, Mudd PA, Akalin E, Ndhlovu LC, Sacha JB. Patterson BK, et al. Int J Infect Dis. 2021 Feb;103:25-32. doi: 10.1016/j.ijid.2020.10.101. Epub 2020 Nov 10. Int J Infect Dis. 2021. PMID: 33186704 Free PMC article.
Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19.
Patterson BK, Seethamraju H, Dhody K, Corley MJ, Kazempour K, Lalezari JP, Pang AP, Sugai C, Francisco EB, Pise A, Rodrigues H, Ryou M, Wu HL, Webb GM, Park BS, Kelly S, Pourhassan N, Lelic A, Kdouh L, Herrera M, Hall E, Aklin E, Ndhlovu L, Sacha JB. Patterson BK, et al. Among authors: pang ap. medRxiv [Preprint]. 2020 May 5:2020.05.02.20084673. doi: 10.1101/2020.05.02.20084673. medRxiv. 2020. PMID: 32511656 Free PMC article. Preprint.
Effects of Brief Adjunctive Metformin Therapy in Virologically Suppressed HIV-Infected Adults on Polyfunctional HIV-Specific CD8 T Cell Responses to PD-L1 Blockade.
Chew GM, Padua AJP, Chow DC, Souza SA, Clements DM, Corley MJ, Pang APS, Alejandria MM, Gerschenson M, Shikuma CM, Ndhlovu LC. Chew GM, et al. AIDS Res Hum Retroviruses. 2021 Jan;37(1):24-33. doi: 10.1089/AID.2020.0172. Epub 2020 Nov 5. AIDS Res Hum Retroviruses. 2021. PMID: 33019813 Free PMC article. Clinical Trial.
48 results