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Understanding Toxoplasmosis in the United States Through "Large Data" Analyses.
Lykins J, Wang K, Wheeler K, Clouser F, Dixon A, El Bissati K, Zhou Y, Lyttle C, Rzhetsky A, McLeod R. Lykins J, et al. Among authors: zhou y. Clin Infect Dis. 2016 Aug 15;63(4):468-75. doi: 10.1093/cid/ciw356. Epub 2016 Jun 26. Clin Infect Dis. 2016. PMID: 27353665 Free PMC article.
Toxoplasma gondii HLA-B*0702-restricted GRA7(20-28) peptide with adjuvants and a universal helper T cell epitope elicits CD8(+) T cells producing interferon-γ and reduces parasite burden in HLA-B*0702 mice.
Cong H, Mui EJ, Witola WH, Sidney J, Alexander J, Sette A, Maewal A, El Bissati K, Zhou Y, Suzuki Y, Lee D, Woods S, Sommerville C, Henriquez FL, Roberts CW, McLeod R. Cong H, et al. Among authors: zhou y. Hum Immunol. 2012 Jan;73(1):1-10. doi: 10.1016/j.humimm.2011.10.006. Epub 2011 Oct 12. Hum Immunol. 2012. PMID: 22027386 Free PMC article.
Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.
Fomovska A, Huang Q, El Bissati K, Mui EJ, Witola WH, Cheng G, Zhou Y, Sommerville C, Roberts CW, Bettis S, Prigge ST, Afanador GA, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Pieroni M, Stec J, Muench SP, Rice DW, Kozikowski AP, McLeod R. Fomovska A, et al. Among authors: zhou y. Antimicrob Agents Chemother. 2012 May;56(5):2666-82. doi: 10.1128/AAC.06450-11. Epub 2012 Feb 21. Antimicrob Agents Chemother. 2012. PMID: 22354304 Free PMC article.
Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii.
Stec J, Fomovska A, Afanador GA, Muench SP, Zhou Y, Lai BS, El Bissati K, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Sommervile C, Woods S, Roberts CW, Rice D, Prigge ST, McLeod R, Kozikowski AP. Stec J, et al. Among authors: zhou y. ChemMedChem. 2013 Jul;8(7):1138-60. doi: 10.1002/cmdc.201300050. Epub 2013 Jun 14. ChemMedChem. 2013. PMID: 23776166 Free PMC article.
The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target.
Wilkinson C, McPhillie MJ, Zhou Y, Woods S, Afanador GA, Rawson S, Khaliq F, Prigge ST, Roberts CW, Rice DW, McLeod R, Fishwick CW, Muench SP. Wilkinson C, et al. Among authors: zhou y. Bioorg Med Chem Lett. 2014 Feb 1;24(3):911-6. doi: 10.1016/j.bmcl.2013.12.066. Epub 2013 Dec 22. Bioorg Med Chem Lett. 2014. PMID: 24398298 Free PMC article.
ALOX12 in human toxoplasmosis.
Witola WH, Liu SR, Montpetit A, Welti R, Hypolite M, Roth M, Zhou Y, Mui E, Cesbron-Delauw MF, Fournie GJ, Cavailles P, Bisanz C, Boyer K, Withers S, Noble AG, Swisher CN, Heydemann PT, Rabiah P, Muench SP, McLeod R. Witola WH, et al. Among authors: zhou y. Infect Immun. 2014 Jul;82(7):2670-9. doi: 10.1128/IAI.01505-13. Epub 2014 Mar 31. Infect Immun. 2014. PMID: 24686056 Free PMC article.
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