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Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.
Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C, Reif R, Stöber R, Hammad S, Pütter L, Gianmoena K, Marchan R, Ghallab A, Edlund K, Nüssler A, Thasler WE, Damm G, Seehofer D, Weiss TS, Dirsch O, Dahmen U, Gebhardt R, Chaudhari U, Meganathan K, Sachinidis A, Kelm J, Hofmann U, Zahedi RP, Guthke R, Blüthgen N, Dooley S, Hengstler JG. Godoy P, et al. Among authors: campos g. Arch Toxicol. 2016 Oct;90(10):2513-29. doi: 10.1007/s00204-016-1761-4. Epub 2016 Jun 23. Arch Toxicol. 2016. PMID: 27339419 Free PMC article.
The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity.
Campos G, Schmidt-Heck W, Ghallab A, Rochlitz K, Pütter L, Medinas DB, Hetz C, Widera A, Cadenas C, Begher-Tibbe B, Reif R, Günther G, Sachinidis A, Hengstler JG, Godoy P. Campos G, et al. Arch Toxicol. 2014 Jun;88(6):1267-80. doi: 10.1007/s00204-014-1240-8. Epub 2014 Apr 20. Arch Toxicol. 2014. PMID: 24748426
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells.
Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, Björquist P, Widera A, Stöber R, Campos G, Hammad S, Sachinidis A, Chaudhari U, Damm G, Weiss TS, Nüssler A, Synnergren J, Edlund K, Küppers-Munther B, Hay DC, Hengstler JG. Godoy P, et al. Among authors: campos g. J Hepatol. 2015 Oct;63(4):934-42. doi: 10.1016/j.jhep.2015.05.013. Epub 2015 May 25. J Hepatol. 2015. PMID: 26022688 Free PMC article.
Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes.
Cameron K, Tan R, Schmidt-Heck W, Campos G, Lyall MJ, Wang Y, Lucendo-Villarin B, Szkolnicka D, Bates N, Kimber SJ, Hengstler JG, Godoy P, Forbes SJ, Hay DC. Cameron K, et al. Among authors: campos g. Stem Cell Reports. 2015 Dec 8;5(6):1250-1262. doi: 10.1016/j.stemcr.2015.10.016. Epub 2015 Nov 25. Stem Cell Reports. 2015. PMID: 26626180 Free PMC article.
Corrigendum to "Gene networks and transcription factor motifs defining the differentiation of human stem cells into hepatocyte-like cells" [J Hepatol 2015;63:934-942].
Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, Björquist P, Widera A, Stöber R, Campos G, Hammad S, Sachinidis A, Chaudhari U, Damm G, Weiss TS, Nüssler A, Synnergren J, Edlund K, Küppers-Munther B, Hay DC, Hengstler JG. Godoy P, et al. Among authors: campos g. J Hepatol. 2016 Feb;64(2):525-526. doi: 10.1016/j.jhep.2015.11.003. Epub 2015 Dec 2. J Hepatol. 2016. PMID: 28743474 Free PMC article. No abstract available.
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease.
Campos G, Schmidt-Heck W, De Smedt J, Widera A, Ghallab A, Pütter L, González D, Edlund K, Cadenas C, Marchan R, Guthke R, Verfaillie C, Hetz C, Sachinidis A, Braeuning A, Schwarz M, Weiß TS, Banhart BK, Hoek J, Vadigepalli R, Willy J, Stevens JL, Hay DC, Hengstler JG, Godoy P. Campos G, et al. Arch Toxicol. 2020 Jan;94(1):205-217. doi: 10.1007/s00204-019-02630-3. Epub 2020 Jan 9. Arch Toxicol. 2020. PMID: 31919559
Role of WISP1 in Stellate Cell Migration and Liver Fibrosis.
González D, Campos G, Pütter L, Friebel A, Holland CH, Holländer L, Ghallab A, Hobloss Z, Myllys M, Hoehme S, Meindl-Beinker NM, Dooley S, Marchan R, Weiss TS, Hengstler JG, Godoy P. González D, et al. Among authors: campos g. Cells. 2024 Sep 29;13(19):1629. doi: 10.3390/cells13191629. Cells. 2024. PMID: 39404393 Free PMC article.
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α.
Sepulveda D, Rojas-Rivera D, Rodríguez DA, Groenendyk J, Köhler A, Lebeaupin C, Ito S, Urra H, Carreras-Sureda A, Hazari Y, Vasseur-Cognet M, Ali MMU, Chevet E, Campos G, Godoy P, Vaisar T, Bailly-Maitre B, Nagata K, Michalak M, Sierralta J, Hetz C. Sepulveda D, et al. Among authors: campos g. Mol Cell. 2018 Jan 18;69(2):238-252.e7. doi: 10.1016/j.molcel.2017.12.028. Mol Cell. 2018. PMID: 29351844 Free article.
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response.
Dufey E, Bravo-San Pedro JM, Eggers C, González-Quiroz M, Urra H, Sagredo AI, Sepulveda D, Pihán P, Carreras-Sureda A, Hazari Y, Sagredo EA, Gutierrez D, Valls C, Papaioannou A, Acosta-Alvear D, Campos G, Domingos PM, Pedeux R, Chevet E, Alvarez A, Godoy P, Walter P, Glavic A, Kroemer G, Hetz C. Dufey E, et al. Among authors: campos g. Nat Commun. 2020 May 14;11(1):2401. doi: 10.1038/s41467-020-15694-y. Nat Commun. 2020. PMID: 32409639 Free PMC article.
870 results