Ramanujan S - Search Results

1

Prospective Design of Anti-Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain.

Kanodia JS, Gadkar K, Bumbaca D, Zhang Y, Tong RK, Luk W, Hoyte K, Lu Y, Wildsmith KR, Couch JA, Watts RJ, Dennis MS, Ernst JA, Scearce-Levie K, Atwal JK, Ramanujan S, Joseph S. Kanodia JS, et al. Among authors: ramanujan s. CPT Pharmacometrics Syst Pharmacol. 2016 May;5(5):283-91. doi: 10.1002/psp4.12081. Epub 2016 May 17. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27299941 Free PMC article.

2

A Mechanistic Systems Pharmacology Model for Prediction of LDL Cholesterol Lowering by PCSK9 Antagonism in Human Dyslipidemic Populations.

Gadkar K, Budha N, Baruch A, Davis JD, Fielder P, Ramanujan S. Gadkar K, et al. Among authors: ramanujan s. CPT Pharmacometrics Syst Pharmacol. 2014 Nov 26;3(11):e149. doi: 10.1038/psp.2014.47. CPT Pharmacometrics Syst Pharmacol. 2014. PMID: 25426564 Free PMC article.

3

Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates.

Sukumaran S, Gadkar K, Zhang C, Bhakta S, Liu L, Xu K, Raab H, Yu SF, Mai E, Fourie-O'Donohue A, Kozak KR, Ramanujan S, Junutula JR, Lin K. Sukumaran S, et al. Among authors: ramanujan s. Pharm Res. 2015 Jun;32(6):1884-93. doi: 10.1007/s11095-014-1582-1. Epub 2014 Dec 2. Pharm Res. 2015. PMID: 25446772

4

Challenges and Opportunities for Quantitative Clinical Pharmacology in Cancer Immunotherapy: Something Old, Something New, Something Borrowed, and Something Blue.

Stroh M, Carlile DJ, Li CC, Wagg J, Ribba B, Ramanujan S, Jin J, Xu J, Charoin JE, Xhu ZX, Morcos PN, Davis JD, Phipps A. Stroh M, et al. Among authors: ramanujan s. CPT Pharmacometrics Syst Pharmacol. 2015 Sep;4(9):495-7. doi: 10.1002/psp4.12014. Epub 2015 Sep 11. CPT Pharmacometrics Syst Pharmacol. 2015. PMID: 26451328 Free PMC article.

5

Evaluation of HDL-modulating interventions for cardiovascular risk reduction using a systems pharmacology approach.

Gadkar K, Lu J, Sahasranaman S, Davis J, Mazer NA, Ramanujan S. Gadkar K, et al. Among authors: ramanujan s. J Lipid Res. 2016 Jan;57(1):46-55. doi: 10.1194/jlr.M057943. Epub 2015 Nov 1. J Lipid Res. 2016. PMID: 26522778 Free PMC article.

6

Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain.

Gadkar K, Yadav DB, Zuchero JY, Couch JA, Kanodia J, Kenrick MK, Atwal JK, Dennis MS, Prabhu S, Watts RJ, Joseph SB, Ramanujan S. Gadkar K, et al. Among authors: ramanujan s. Eur J Pharm Biopharm. 2016 Apr;101:53-61. doi: 10.1016/j.ejpb.2016.01.009. Epub 2016 Jan 25. Eur J Pharm Biopharm. 2016. PMID: 26820920

7

A Six-Stage Workflow for Robust Application of Systems Pharmacology.

Gadkar K, Kirouac DC, Mager DE, van der Graaf PH, Ramanujan S. Gadkar K, et al. Among authors: ramanujan s. CPT Pharmacometrics Syst Pharmacol. 2016 May;5(5):235-49. doi: 10.1002/psp4.12071. Epub 2016 Apr 16. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27299936 Free PMC article.

8

Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics.

Sukumaran S, Zhang C, Leipold DD, Saad OM, Xu K, Gadkar K, Samineni D, Wang B, Milojic-Blair M, Carrasco-Triguero M, Rubinfeld B, Fielder P, Lin K, Ramanujan S. Sukumaran S, et al. Among authors: ramanujan s. AAPS J. 2017 Jan;19(1):130-140. doi: 10.1208/s12248-016-9993-z. Epub 2016 Sep 27. AAPS J. 2017. PMID: 27679517

9

Quantitative systems pharmacology: a promising approach for translational pharmacology.

Gadkar K, Kirouac D, Parrott N, Ramanujan S. Gadkar K, et al. Among authors: ramanujan s. Drug Discov Today Technol. 2016 Sep-Dec;21-22:57-65. doi: 10.1016/j.ddtec.2016.11.001. Epub 2016 Nov 24. Drug Discov Today Technol. 2016. PMID: 27978989 Review.

10

Clinical responses to ERK inhibition in BRAF^V600E-mutant colorectal cancer predicted using a computational model.

Kirouac DC, Schaefer G, Chan J, Merchant M, Orr C, Huang SA, Moffat J, Liu L, Gadkar K, Ramanujan S. Kirouac DC, et al. Among authors: ramanujan s. NPJ Syst Biol Appl. 2017 Jun 2;3:14. doi: 10.1038/s41540-017-0016-1. eCollection 2017. NPJ Syst Biol Appl. 2017. PMID: 28649441 Free PMC article.

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