Meek MEB - Search Results

1

Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity.

Bal-Price A, Lein PJ, Keil KP, Sethi S, Shafer T, Barenys M, Fritsche E, Sachana M, Meek MEB. Bal-Price A, et al. Among authors: meek meb. Neurotoxicology. 2017 Mar;59:240-255. doi: 10.1016/j.neuro.2016.05.010. Epub 2016 May 17. Neurotoxicology. 2017. PMID: 27212452 Free PMC article. Review.

2

Adverse outcome pathways: Application to enhance mechanistic understanding of neurotoxicity.

Bal-Price A, Meek MEB. Bal-Price A, et al. Among authors: meek meb. Pharmacol Ther. 2017 Nov;179:84-95. doi: 10.1016/j.pharmthera.2017.05.006. Epub 2017 May 18. Pharmacol Ther. 2017. PMID: 28529068 Free PMC article. Review.

3

Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment.

Meek ME, Klaunig JE. Meek ME, et al. Chem Biol Interact. 2010 Mar 19;184(1-2):279-85. doi: 10.1016/j.cbi.2010.02.006. Epub 2010 Feb 11. Chem Biol Interact. 2010. PMID: 20153303

4

Application of benchmark dose modeling to protein expression data in the development and analysis of mode of action/adverse outcome pathways for testicular toxicity.

Chepelev NL, Meek ME, Yauk CL. Chepelev NL, et al. J Appl Toxicol. 2014 Nov;34(11):1115-21. doi: 10.1002/jat.3071. Epub 2014 Sep 22. J Appl Toxicol. 2014. PMID: 25244189 Review.

5

Gaining acceptance for the use of in vitro toxicity assays and QIVIVE in regulatory risk assessment.

Meek ME, Lipscomb JC. Meek ME, et al. Toxicology. 2015 Jun 5;332:112-23. doi: 10.1016/j.tox.2015.01.010. Epub 2015 Jan 15. Toxicology. 2015. PMID: 25598226 Review.

6

Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement.

Yauk CL, Lambert IB, Meek ME, Douglas GR, Marchetti F. Yauk CL, et al. Environ Mol Mutagen. 2015 Dec;56(9):724-50. doi: 10.1002/em.21954. Epub 2015 May 22. Environ Mol Mutagen. 2015. PMID: 26010389

7

How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology.

Wittwehr C, Aladjov H, Ankley G, Byrne HJ, de Knecht J, Heinzle E, Klambauer G, Landesmann B, Luijten M, MacKay C, Maxwell G, Meek ME, Paini A, Perkins E, Sobanski T, Villeneuve D, Waters KM, Whelan M. Wittwehr C, et al. Toxicol Sci. 2017 Feb;155(2):326-336. doi: 10.1093/toxsci/kfw207. Epub 2016 Dec 19. Toxicol Sci. 2017. PMID: 27994170 Free PMC article.

8

Framework for human health risk assessment of non-cancer effects resulting from short-duration and intermittent exposures to chemicals.

Haber LT, Sandhu R, Li-Muller A, Mohapatra A, Petrovic S, Meek ME. Haber LT, et al. J Appl Toxicol. 2016 Sep;36(9):1077-89. doi: 10.1002/jat.3345. Epub 2016 Jun 14. J Appl Toxicol. 2016. PMID: 27297613

9

A framework for human relevance analysis of information on carcinogenic modes of action.

Meek ME, Bucher JR, Cohen SM, Dellarco V, Hill RN, Lehman-McKeeman LD, Longfellow DG, Pastoor T, Seed J, Patton DE. Meek ME, et al. Crit Rev Toxicol. 2003;33(6):591-653. doi: 10.1080/713608373. Crit Rev Toxicol. 2003. PMID: 14727733 Review.

10

Recent developments in frameworks to consider human relevance of hypothesized modes of action for tumours in animals.

Meek ME. Meek ME. Environ Mol Mutagen. 2008 Mar;49(2):110-6. doi: 10.1002/em.20369. Environ Mol Mutagen. 2008. PMID: 18213650 Review.

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