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ISG15 deficiency and increased viral resistance in humans but not mice.
Speer SD, Li Z, Buta S, Payelle-Brogard B, Qian L, Vigant F, Rubino E, Gardner TJ, Wedeking T, Hermann M, Duehr J, Sanal O, Tezcan I, Mansouri N, Tabarsi P, Mansouri D, Francois-Newton V, Daussy CF, Rodriguez MR, Lenschow DJ, Freiberg AN, Tortorella D, Piehler J, Lee B, García-Sastre A, Pellegrini S, Bogunovic D. Speer SD, et al. Nat Commun. 2016 May 19;7:11496. doi: 10.1038/ncomms11496. Nat Commun. 2016. PMID: 27193971 Free PMC article.
IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.
Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, Osiak A, Levine B, Schmidt RE, García-Sastre A, Leib DA, Pekosz A, Knobeloch KP, Horak I, Virgin HW 4th. Lenschow DJ, et al. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1371-6. doi: 10.1073/pnas.0607038104. Epub 2007 Jan 16. Proc Natl Acad Sci U S A. 2007. PMID: 17227866 Free PMC article.
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.
Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM. Schoggins JW, et al. Nature. 2014 Jan 30;505(7485):691-5. doi: 10.1038/nature12862. Epub 2013 Nov 27. Nature. 2014. PMID: 24284630 Free PMC article.
821 results