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Platelet sequestration and activation during GalTKO.hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and von Willebrand Factor.
Burdorf L, Riner A, Rybak E, Salles II, De Meyer SF, Shah A, Quinn KJ, Harris D, Zhang T, Parsell D, Ali F, Schwartz E, Kang E, Cheng X, Sievert E, Zhao Y, Braileanu G, Phelps CJ, Ayares DL, Deckmyn H, Pierson RN 3rd, Azimzadeh AM, Dandro A, Karavi K. Burdorf L, et al. Among authors: karavi k. Xenotransplantation. 2016 May;23(3):222-236. doi: 10.1111/xen.12236. Epub 2016 May 18. Xenotransplantation. 2016. PMID: 27188532 Free PMC article.
Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood.
Miura S, Habibabady ZA, Pollok F, Connolly M, Pratts S, Dandro A, Sorrells L, Karavi K, Phelps C, Eyestone W, Ayares D, Burdorf L, Azimzadeh A, Pierson RN 3rd. Miura S, et al. Among authors: karavi k. Xenotransplantation. 2022 Mar;29(2):e12725. doi: 10.1111/xen.12725. Epub 2022 Mar 2. Xenotransplantation. 2022. PMID: 35234315 Free PMC article.