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Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation.
Rialdi A, Campisi L, Zhao N, Lagda AC, Pietzsch C, Ho JSY, Martinez-Gil L, Fenouil R, Chen X, Edwards M, Metreveli G, Jordan S, Peralta Z, Munoz-Fontela C, Bouvier N, Merad M, Jin J, Weirauch M, Heinz S, Benner C, van Bakel H, Basler C, García-Sastre A, Bukreyev A, Marazzi I. Rialdi A, et al. Among authors: edwards m. Science. 2016 May 27;352(6289):aad7993. doi: 10.1126/science.aad7993. Epub 2016 Apr 28. Science. 2016. PMID: 27127234 Free PMC article.
Structural basis for Marburg virus VP35-mediated immune evasion mechanisms.
Ramanan P, Edwards MR, Shabman RS, Leung DW, Endlich-Frazier AC, Borek DM, Otwinowski Z, Liu G, Huh J, Basler CF, Amarasinghe GK. Ramanan P, et al. Among authors: edwards mr. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20661-6. doi: 10.1073/pnas.1213559109. Epub 2012 Nov 26. Proc Natl Acad Sci U S A. 2012. PMID: 23185024 Free PMC article.
Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.
Xu W, Edwards MR, Borek DM, Feagins AR, Mittal A, Alinger JB, Berry KN, Yen B, Hamilton J, Brett TJ, Pappu RV, Leung DW, Basler CF, Amarasinghe GK. Xu W, et al. Among authors: edwards mr. Cell Host Microbe. 2014 Aug 13;16(2):187-200. doi: 10.1016/j.chom.2014.07.008. Cell Host Microbe. 2014. PMID: 25121748 Free PMC article.
5,165 results