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Human retinal organoids release extracellular vesicles that regulate gene expression in target human retinal progenitor cells.
Zhou J, Flores-Bellver M, Pan J, Benito-Martin A, Shi C, Onwumere O, Mighty J, Qian J, Zhong X, Hogue T, Amponsah-Antwi B, Einbond L, Gharbaran R, Wu H, Chen BJ, Zheng Z, Tchaikovskaya T, Zhang X, Peinado H, Canto-Soler MV, Redenti S. Zhou J, et al. Sci Rep. 2021 Oct 26;11(1):21128. doi: 10.1038/s41598-021-00542-w. Sci Rep. 2021. PMID: 34702879 Free PMC article.
PAI-1 is a vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal neovascularization in diabetic patients.
Qin Y, Zhang J, Babapoor-Farrokhran S, Applewhite B, Deshpande M, Megarity H, Flores-Bellver M, Aparicio-Domingo S, Ma T, Rui Y, Tzeng SY, Green JJ, Canto-Soler MV, Montaner S, Sodhi A. Qin Y, et al. Sci Adv. 2022 Mar 4;8(9):eabm1896. doi: 10.1126/sciadv.abm1896. Epub 2022 Mar 2. Sci Adv. 2022. PMID: 35235351 Free PMC article.
HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease.
Zhang J, Qin Y, Martinez M, Flores-Bellver M, Rodrigues M, Dinabandhu A, Cao X, Deshpande M, Qin Y, Aparicio-Domingo S, Rui Y, Tzeng SY, Salman S, Yuan J, Scott AW, Green JJ, Canto-Soler MV, Semenza GL, Montaner S, Sodhi A. Zhang J, et al. J Clin Invest. 2021 Jun 15;131(12):e139202. doi: 10.1172/JCI139202. J Clin Invest. 2021. PMID: 34128478 Free PMC article.
Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors.
Flores-Bellver M, Mighty J, Aparicio-Domingo S, Li KV, Shi C, Zhou J, Cobb H, McGrath P, Michelis G, Lenhart P, Bilousova G, Heissel S, Rudy MJ, Coughlan C, Goodspeed AE, Becerra SP, Redenti S, Canto-Soler MV. Flores-Bellver M, et al. J Extracell Vesicles. 2021 Nov;10(13):e12165. doi: 10.1002/jev2.12165. J Extracell Vesicles. 2021. PMID: 34750957 Free PMC article.
30 results