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Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.
Fraser C, Dawson JC, Dowling R, Houston DR, Weiss JT, Munro AF, Muir M, Harrington L, Webster SP, Frame MC, Brunton VG, Patton EE, Carragher NO, Unciti-Broceta A. Fraser C, et al. Among authors: frame mc. J Med Chem. 2016 May 26;59(10):4697-710. doi: 10.1021/acs.jmedchem.6b00065. Epub 2016 May 4. J Med Chem. 2016. PMID: 27115835 Free PMC article.
v-Src's hold over actin and cell adhesions.
Frame MC, Fincham VJ, Carragher NO, Wyke JA. Frame MC, et al. Nat Rev Mol Cell Biol. 2002 Apr;3(4):233-45. doi: 10.1038/nrm779. Nat Rev Mol Cell Biol. 2002. PMID: 11994743 Review.
Calpain: a role in cell transformation and migration.
Carragher NO, Frame MC. Carragher NO, et al. Among authors: frame mc. Int J Biochem Cell Biol. 2002 Dec;34(12):1539-43. doi: 10.1016/s1357-2725(02)00069-9. Int J Biochem Cell Biol. 2002. PMID: 12379276 Review.
Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis.
Griffiths GJ, Koh MY, Brunton VG, Cawthorne C, Reeves NA, Greaves M, Tilby MJ, Pearson DG, Ottley CJ, Workman P, Frame MC, Dive C. Griffiths GJ, et al. Among authors: frame mc. J Biol Chem. 2004 Oct 29;279(44):46113-21. doi: 10.1074/jbc.M408550200. Epub 2004 Aug 23. J Biol Chem. 2004. PMID: 15326164 Free article.
179 results