Goldsworthy M - Search Results

1

Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion.

Collins SC, Do HW, Hastoy B, Hugill A, Adam J, Chibalina MV, Galvanovskis J, Godazgar M, Lee S, Goldsworthy M, Salehi A, Tarasov AI, Rosengren AH, Cox R, Rorsman P. Collins SC, et al. Among authors: goldsworthy m. Diabetes. 2016 Jul;65(7):1952-61. doi: 10.2337/db15-1489. Epub 2016 Mar 18. Diabetes. 2016. PMID: 26993066 Free PMC article.

2

Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance.

Goldsworthy M, Hugill A, Freeman H, Horner E, Shimomura K, Bogani D, Pieles G, Mijat V, Arkell R, Bhattacharya S, Ashcroft FM, Cox RD. Goldsworthy M, et al. Diabetes. 2008 Aug;57(8):2234-44. doi: 10.2337/db07-0337. Epub 2008 May 13. Diabetes. 2008. PMID: 18477811 Free PMC article.

3

A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.

Toye AA, Moir L, Hugill A, Bentley L, Quarterman J, Mijat V, Hough T, Goldsworthy M, Haynes A, Hunter AJ, Browne M, Spurr N, Cox RD. Toye AA, et al. Among authors: goldsworthy m. Diabetes. 2004 Jun;53(6):1577-83. doi: 10.2337/diabetes.53.6.1577. Diabetes. 2004. PMID: 15161764

4

Insulin secretion from beta-cells is affected by deletion of nicotinamide nucleotide transhydrogenase.

Shimomura K, Galvanovskis J, Goldsworthy M, Hugill A, Kaizak S, Lee A, Meadows N, Quwailid MM, Rydström J, Teboul L, Ashcroft F, Cox RD. Shimomura K, et al. Among authors: goldsworthy m. Methods Enzymol. 2009;457:451-80. doi: 10.1016/S0076-6879(09)05025-3. Methods Enzymol. 2009. PMID: 19426883 Free PMC article.

5

Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes.

Goldsworthy M, Bai Y, Li CM, Ge H, Lamas E, Hilton H, Esapa CT, Baker D, Baron W, Juan T, Véniant MM, Lloyd DJ, Cox RD. Goldsworthy M, et al. Diabetes. 2016 May;65(5):1434-46. doi: 10.2337/db15-1276. Epub 2016 Feb 11. Diabetes. 2016. PMID: 26868295 Free PMC article.

6

A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.

Toye AA, Lippiat JD, Proks P, Shimomura K, Bentley L, Hugill A, Mijat V, Goldsworthy M, Moir L, Haynes A, Quarterman J, Freeman HC, Ashcroft FM, Cox RD. Toye AA, et al. Among authors: goldsworthy m. Diabetologia. 2005 Apr;48(4):675-86. doi: 10.1007/s00125-005-1680-z. Epub 2005 Feb 24. Diabetologia. 2005. PMID: 15729571 Free article.

7

A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes.

Muhsin NIA, Bentley L, Bai Y, Goldsworthy M, Cox RD. Muhsin NIA, et al. Among authors: goldsworthy m. Mamm Genome. 2020 Feb;31(1-2):17-29. doi: 10.1007/s00335-020-09826-4. Epub 2020 Jan 23. Mamm Genome. 2020. PMID: 31974728 Free PMC article.

8

Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.

Goldsworthy M, Absalom NL, Schröter D, Matthews HC, Bogani D, Moir L, Long A, Church C, Hugill A, Anstee QM, Goldin R, Thursz M, Hollfelder F, Cox RD. Goldsworthy M, et al. PLoS One. 2013 Jun 24;8(6):e61870. doi: 10.1371/journal.pone.0061870. Print 2013. PLoS One. 2013. PMID: 23826075 Free PMC article.

9

NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice.

Meimaridou E, Goldsworthy M, Chortis V, Fragouli E, Foster PA, Arlt W, Cox R, Metherell LA. Meimaridou E, et al. Among authors: goldsworthy m. J Endocrinol. 2018 Jan;236(1):13-28. doi: 10.1530/JOE-16-0638. Epub 2017 Oct 18. J Endocrinol. 2018. PMID: 29046340 Free PMC article.

10

New semidominant mutations that affect mouse development.

Bogani D, Warr N, Elms P, Davies J, Tymowska-Lalanne Z, Goldsworthy M, Cox RD, Keays DA, Flint J, Wilson V, Nolan P, Arkell R. Bogani D, et al. Among authors: goldsworthy m. Genesis. 2004 Oct;40(2):109-117. doi: 10.1002/gene.20071. Genesis. 2004. PMID: 15384171

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