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Page 1
The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine.
Göktuna SI, Shostak K, Chau TL, Heukamp LC, Hennuy B, Duong HQ, Ladang A, Close P, Klevernic I, Olivier F, Florin A, Ehx G, Baron F, Vandereyken M, Rahmouni S, Vereecke L, van Loo G, Büttner R, Greten FR, Chariot A. Göktuna SI, et al. Cancer Res. 2016 May 1;76(9):2587-99. doi: 10.1158/0008-5472.CAN-15-1473. Epub 2016 Mar 15. Cancer Res. 2016. PMID: 26980769 Free article.
Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.
Ladang A, Rapino F, Heukamp LC, Tharun L, Shostak K, Hermand D, Delaunay S, Klevernic I, Jiang Z, Jacques N, Jamart D, Migeot V, Florin A, Göktuna S, Malgrange B, Sansom OJ, Nguyen L, Büttner R, Close P, Chariot A. Ladang A, et al. J Exp Med. 2015 Nov 16;212(12):2057-75. doi: 10.1084/jem.20142288. Epub 2015 Nov 2. J Exp Med. 2015. PMID: 26527802 Free PMC article.
IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells.
Göktuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, Taketo MM, Chariot A, Arkan MC, Greten FR. Göktuna SI, et al. Cell Rep. 2014 Jun 26;7(6):1914-25. doi: 10.1016/j.celrep.2014.05.006. Epub 2014 May 29. Cell Rep. 2014. PMID: 24882009 Free PMC article.
NF-κB-induced KIAA1199 promotes survival through EGFR signalling.
Shostak K, Zhang X, Hubert P, Göktuna SI, Jiang Z, Klevernic I, Hildebrand J, Roncarati P, Hennuy B, Ladang A, Somja J, Gothot A, Close P, Delvenne P, Chariot A. Shostak K, et al. Among authors: goktuna si. Nat Commun. 2014 Nov 4;5:5232. doi: 10.1038/ncomms6232. Nat Commun. 2014. PMID: 25366117 Free PMC article.
A role for APPL1 in TLR3/4-dependent TBK1 and IKKε activation in macrophages.
Chau TL, Göktuna SI, Rammal A, Casanova T, Duong HQ, Gatot JS, Close P, Dejardin E, Desmecht D, Shostak K, Chariot A. Chau TL, et al. Among authors: goktuna si. J Immunol. 2015 Apr 15;194(8):3970-83. doi: 10.4049/jimmunol.1401614. Epub 2015 Mar 16. J Immunol. 2015. PMID: 25780039
Correction: Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.
Ladang A, Rapino F, Heukamp LC, Tharun L, Shostak K, Hermand D, Delaunay S, Klevernic I, Jiang Z, Jacques N, Jamart D, Migeot V, Florin A, Göktuna S, Malgrange B, Sansom OJ, Nguyen L, Büttner R, Close P, Chariot A. Ladang A, et al. J Exp Med. 2017 Apr 3;214(4):1199. doi: 10.1084/jem.2014228803082017c. Epub 2017 Mar 10. J Exp Med. 2017. PMID: 28283535 Free PMC article. No abstract available.
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.
Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, Greten FR. Schwitalla S, et al. Among authors: goktuna si. Cell. 2013 Jan 17;152(1-2):25-38. doi: 10.1016/j.cell.2012.12.012. Epub 2012 Dec 27. Cell. 2013. PMID: 23273993 Free article.
IKKs and tumor cell plasticity.
Göktuna SI, Diamanti MA, Chau TL. Göktuna SI, et al. FEBS J. 2018 Jun;285(12):2161-2181. doi: 10.1111/febs.14444. Epub 2018 Apr 17. FEBS J. 2018. PMID: 29582565 Free article. Review.
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.
Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Göktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N, Xu Y, O'Cain T, Jaffee BB, Busch DH, Duyster J, Schmid RM, Eckmann L, Karin M. Greten FR, et al. Among authors: goktuna si. Cell. 2007 Sep 7;130(5):918-31. doi: 10.1016/j.cell.2007.07.009. Cell. 2007. PMID: 17803913 Free PMC article.
14 results