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Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.
Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WHW, DiDonato JA, Brown JM, Lusis AJ, Hazen SL. Zhu W, et al. Cell. 2016 Mar 24;165(1):111-124. doi: 10.1016/j.cell.2016.02.011. Epub 2016 Mar 10. Cell. 2016. PMID: 26972052 Free PMC article.
Transmission of atherosclerosis susceptibility with gut microbial transplantation.
Gregory JC, Buffa JA, Org E, Wang Z, Levison BS, Zhu W, Wagner MA, Bennett BJ, Li L, DiDonato JA, Lusis AJ, Hazen SL. Gregory JC, et al. Among authors: zhu w. J Biol Chem. 2015 Feb 27;290(9):5647-60. doi: 10.1074/jbc.M114.618249. Epub 2014 Dec 30. J Biol Chem. 2015. PMID: 25550161 Free PMC article.
Gut Microbiota-Dependent Trimethylamine N-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes.
Haghikia A, Li XS, Liman TG, Bledau N, Schmidt D, Zimmermann F, Kränkel N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Fraccarollo D, Heimesaat MM, Bauersachs J, Wang Z, Zhu W, Bavendiek U, Hazen SL, Endres M, Landmesser U. Haghikia A, et al. Among authors: zhu w. Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2225-2235. doi: 10.1161/ATVBAHA.118.311023. Arterioscler Thromb Vasc Biol. 2018. PMID: 29976769 Free PMC article.
Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk.
Zhu W, Buffa JA, Wang Z, Warrier M, Schugar R, Shih DM, Gupta N, Gregory JC, Org E, Fu X, Li L, DiDonato JA, Lusis AJ, Brown JM, Hazen SL. Zhu W, et al. J Thromb Haemost. 2018 Sep;16(9):1857-1872. doi: 10.1111/jth.14234. Epub 2018 Aug 9. J Thromb Haemost. 2018. PMID: 29981269 Free PMC article.
Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential.
Roberts AB, Gu X, Buffa JA, Hurd AG, Wang Z, Zhu W, Gupta N, Skye SM, Cody DB, Levison BS, Barrington WT, Russell MW, Reed JM, Duzan A, Lang JM, Fu X, Li L, Myers AJ, Rachakonda S, DiDonato JA, Brown JM, Gogonea V, Lusis AJ, Garcia-Garcia JC, Hazen SL. Roberts AB, et al. Among authors: zhu w. Nat Med. 2018 Sep;24(9):1407-1417. doi: 10.1038/s41591-018-0128-1. Epub 2018 Aug 6. Nat Med. 2018. PMID: 30082863 Free PMC article.
Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential.
Skye SM, Zhu W, Romano KA, Guo CJ, Wang Z, Jia X, Kirsop J, Haag B, Lang JM, DiDonato JA, Tang WHW, Lusis AJ, Rey FE, Fischbach MA, Hazen SL. Skye SM, et al. Among authors: zhu w. Circ Res. 2018 Oct 26;123(10):1164-1176. doi: 10.1161/CIRCRESAHA.118.313142. Circ Res. 2018. PMID: 30359185 Free PMC article. Clinical Trial.
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