Barton HA - Search Results

1

Does the Systemic Plasma Profile Inform the Liver Profile? Analysis Using a Physiologically Based Pharmacokinetic Model and Individual Compounds.

Li R, Maurer TS, Sweeney K, Barton HA. Li R, et al. Among authors: barton ha. AAPS J. 2016 May;18(3):746-56. doi: 10.1208/s12248-016-9895-0. Epub 2016 Mar 7. AAPS J. 2016. PMID: 26951483 Free PMC article.

2

A Mechanistic Pharmacokinetic Model for Liver Transporter Substrates Under Liver Cirrhosis Conditions.

Li R, Barton HA, Maurer TS. Li R, et al. Among authors: barton ha. CPT Pharmacometrics Syst Pharmacol. 2015 Jun;4(6):338-49. doi: 10.1002/psp4.39. Epub 2015 Jun 1. CPT Pharmacometrics Syst Pharmacol. 2015. PMID: 26225262 Free PMC article.

3

A "middle-out" approach to human pharmacokinetic predictions for OATP substrates using physiologically-based pharmacokinetic modeling.

Li R, Barton HA, Yates PD, Ghosh A, Wolford AC, Riccardi KA, Maurer TS. Li R, et al. Among authors: barton ha. J Pharmacokinet Pharmacodyn. 2014 Jun;41(3):197-209. doi: 10.1007/s10928-014-9357-1. Epub 2014 Apr 10. J Pharmacokinet Pharmacodyn. 2014. PMID: 24718648

4

Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved.

Li R, Barton HA, Varma MV. Li R, et al. Among authors: barton ha. Clin Pharmacokinet. 2014 Aug;53(8):659-78. doi: 10.1007/s40262-014-0156-z. Clin Pharmacokinet. 2014. PMID: 25056496 Review.

5

Physiologically based pharmacokinetic prediction of telmisartan in human.

Li R, Ghosh A, Maurer TS, Kimoto E, Barton HA. Li R, et al. Among authors: barton ha. Drug Metab Dispos. 2014 Oct;42(10):1646-55. doi: 10.1124/dmd.114.058461. Epub 2014 Aug 4. Drug Metab Dispos. 2014. PMID: 25092714

6

Toward Prospective Prediction of Pharmacokinetics in OATP1B1 Genetic Variant Populations.

Li R, Barton HA, Maurer TS. Li R, et al. Among authors: barton ha. CPT Pharmacometrics Syst Pharmacol. 2014 Dec 10;3(12):e151. doi: 10.1038/psp.2014.50. CPT Pharmacometrics Syst Pharmacol. 2014. PMID: 25494035 Free PMC article.

7

Explaining Ethnic Variability of Transporter Substrate Pharmacokinetics in Healthy Asian and Caucasian Subjects with Allele Frequencies of OATP1B1 and BCRP: A Mechanistic Modeling Analysis.

Li R, Barton HA. Li R, et al. Among authors: barton ha. Clin Pharmacokinet. 2018 Apr;57(4):491-503. doi: 10.1007/s40262-017-0568-7. Clin Pharmacokinet. 2018. PMID: 28653144 Free PMC article.

8

Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.

Jones HM, Barton HA, Lai Y, Bi YA, Kimoto E, Kempshall S, Tate SC, El-Kattan A, Houston JB, Galetin A, Fenner KS. Jones HM, et al. Among authors: barton ha. Drug Metab Dispos. 2012 May;40(5):1007-17. doi: 10.1124/dmd.111.042994. Epub 2012 Feb 16. Drug Metab Dispos. 2012. PMID: 22344703

9

A Physiologically-Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data.

Jones HM, Zhang Z, Jasper P, Luo H, Avery LB, King LE, Neubert H, Barton HA, Betts AM, Webster R. Jones HM, et al. Among authors: barton ha. CPT Pharmacometrics Syst Pharmacol. 2019 Oct;8(10):738-747. doi: 10.1002/psp4.12461. Epub 2019 Sep 23. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31464379 Free PMC article.

10

In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation.

Bi YA, Kimoto E, Sevidal S, Jones HM, Barton HA, Kempshall S, Whalen KM, Zhang H, Ji C, Fenner KS, El-Kattan AF, Lai Y. Bi YA, et al. Among authors: barton ha. Drug Metab Dispos. 2012 Jun;40(6):1085-92. doi: 10.1124/dmd.111.043489. Epub 2012 Mar 1. Drug Metab Dispos. 2012. PMID: 22381335 Review.

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