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Attacking the supply wagons to starve cancer cells to death.
Selwan EM, Finicle BT, Kim SM, Edinger AL. Selwan EM, et al. Among authors: kim sm. FEBS Lett. 2016 Apr;590(7):885-907. doi: 10.1002/1873-3468.12121. Epub 2016 Mar 22. FEBS Lett. 2016. PMID: 26938658 Free PMC article. Review.
Loss of TSC2 confers resistance to ceramide and nutrient deprivation.
Guenther GG, Liu G, Ramirez MU, McMonigle RJ, Kim SM, McCracken AN, Joo Y, Ushach I, Nguyen NL, Edinger AL. Guenther GG, et al. Among authors: kim sm. Oncogene. 2014 Apr 3;33(14):1776-87. doi: 10.1038/onc.2013.139. Epub 2013 Apr 22. Oncogene. 2014. PMID: 23604129 Free PMC article.
Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death.
Perryman MS, Tessier J, Wiher T, O'Donoghue H, McCracken AN, Kim SM, Nguyen DG, Simitian GS, Viana M, Rafelski S, Edinger AL, Hanessian S. Perryman MS, et al. Among authors: kim sm. Bioorg Med Chem. 2016 Sep 15;24(18):4390-4397. doi: 10.1016/j.bmc.2016.07.038. Epub 2016 Jul 18. Bioorg Med Chem. 2016. PMID: 27475534
Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation.
McCracken AN, McMonigle RJ, Tessier J, Fransson R, Perryman MS, Chen B, Keebaugh A, Selwan E, Barr SA, Kim SM, Roy SG, Liu G, Fallegger D, Sernissi L, Brandt C, Moitessier N, Snider AJ, Clare S, Müschen M, Huwiler A, Kleinman MT, Hanessian S, Edinger AL. McCracken AN, et al. Among authors: kim sm. Leukemia. 2017 Mar;31(3):669-677. doi: 10.1038/leu.2016.244. Epub 2016 Aug 30. Leukemia. 2017. PMID: 27573555 Free PMC article.
Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.
Kim SM, Roy SG, Chen B, Nguyen TM, McMonigle RJ, McCracken AN, Zhang Y, Kofuji S, Hou J, Selwan E, Finicle BT, Nguyen TT, Ravi A, Ramirez MU, Wiher T, Guenther GG, Kono M, Sasaki AT, Weisman LS, Potma EO, Tromberg BJ, Edwards RA, Hanessian S, Edinger AL. Kim SM, et al. J Clin Invest. 2016 Nov 1;126(11):4088-4102. doi: 10.1172/JCI87148. Epub 2016 Sep 26. J Clin Invest. 2016. PMID: 27669461 Free PMC article.
A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion.
Kofuji S, Wolfe K, Sumita K, Kageyama S, Yoshino H, Hirota Y, Ogawa-Iio A, Kanoh H, Sasaki M, Kofuji K, Davis MI, Pragani R, Shen M, Boxer MB, Nakatsu F, Nigorikawa K, Sasaki T, Takeuchi K, Senda T, Kim SM, Edinger AL, Simeonov A, Sasaki AT. Kofuji S, et al. Among authors: kim sm. Biochem Biophys Res Commun. 2024 Jul 23;718:149981. doi: 10.1016/j.bbrc.2024.149981. Epub 2024 Apr 27. Biochem Biophys Res Commun. 2024. PMID: 38735134
B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies.
Lee S, Chae SJ, Jang IH, Oh SC, Kim SM, Lee SY, Kim JH, Ko J, Kim HJ, Song IC, Kim JK, Kim TD. Lee S, et al. Among authors: kim sm. EBioMedicine. 2024 Nov 22;110:105459. doi: 10.1016/j.ebiom.2024.105459. Online ahead of print. EBioMedicine. 2024. PMID: 39579618 Free article.
4,573 results