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The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.
Purbhoo MA, Boulter JM, Price DA, Vuidepot AL, Hourigan CS, Dunbar PR, Olson K, Dawson SJ, Phillips RE, Jakobsen BK, Bell JI, Sewell AK. Purbhoo MA, et al. Among authors: sewell ak. J Biol Chem. 2001 Aug 31;276(35):32786-92. doi: 10.1074/jbc.M102498200. Epub 2001 Jul 3. J Biol Chem. 2001. PMID: 11438524 Free article.
Novel CD8+ T cell antagonists based on beta 2-microglobulin.
Glick M, Price DA, Vuidepot AL, Andersen TB, Hutchinson SL, Laugel B, Sewell AK, Boulter JM, Dunbar PR, Cerundolo V, Oxenius A, Bell JI, Richards WG, Jakobsen BK. Glick M, et al. Among authors: sewell ak. J Biol Chem. 2002 Jun 7;277(23):20840-6. doi: 10.1074/jbc.M201819200. Epub 2002 Mar 25. J Biol Chem. 2002. PMID: 11914379 Free article.
Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface.
Wooldridge L, van den Berg HA, Glick M, Gostick E, Laugel B, Hutchinson SL, Milicic A, Brenchley JM, Douek DC, Price DA, Sewell AK. Wooldridge L, et al. Among authors: sewell ak. J Biol Chem. 2005 Jul 29;280(30):27491-501. doi: 10.1074/jbc.M500555200. Epub 2005 Apr 18. J Biol Chem. 2005. PMID: 15837791 Free PMC article.
Structural and kinetic basis for heightened immunogenicity of T cell vaccines.
Chen JL, Stewart-Jones G, Bossi G, Lissin NM, Wooldridge L, Choi EM, Held G, Dunbar PR, Esnouf RM, Sami M, Boulter JM, Rizkallah P, Renner C, Sewell A, van der Merwe PA, Jakobsen BK, Griffiths G, Jones EY, Cerundolo V. Chen JL, et al. J Exp Med. 2005 Apr 18;201(8):1243-55. doi: 10.1084/jem.20042323. J Exp Med. 2005. PMID: 15837811 Free PMC article.
Human TCR-binding affinity is governed by MHC class restriction.
Cole DK, Pumphrey NJ, Boulter JM, Sami M, Bell JI, Gostick E, Price DA, Gao GF, Sewell AK, Jakobsen BK. Cole DK, et al. Among authors: sewell ak. J Immunol. 2007 May 1;178(9):5727-34. doi: 10.4049/jimmunol.178.9.5727. J Immunol. 2007. PMID: 17442956
212 results