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Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.
Senol SP, Temiz M, Guden DS, Cecen P, Sari AN, Sahan-Firat S, Falck JR, Dakarapu R, Malik KU, Tunctan B. Senol SP, et al. Among authors: malik ku. Inflamm Res. 2016 May;65(5):367-87. doi: 10.1007/s00011-016-0922-5. Epub 2016 Feb 13. Inflamm Res. 2016. PMID: 26875149
A synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats.
Cuez T, Korkmaz B, Buharalioglu CK, Sahan-Firat S, Falck J, Malik KU, Tunctan B. Cuez T, et al. Among authors: malik ku. Basic Clin Pharmacol Toxicol. 2010 May;106(5):378-88. doi: 10.1111/j.1742-7843.2009.00501.x. Epub 2009 Dec 7. Basic Clin Pharmacol Toxicol. 2010. PMID: 20002062 Free PMC article.
231 results