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Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage.
Jiang F, Taylor DW, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA. Jiang F, et al. Science. 2016 Feb 19;351(6275):867-71. doi: 10.1126/science.aad8282. Epub 2016 Jan 14. Science. 2016. PMID: 26841432 Free PMC article.
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.
Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA. Jinek M, et al. Among authors: jiang f. Science. 2014 Mar 14;343(6176):1247997. doi: 10.1126/science.1247997. Epub 2014 Feb 6. Science. 2014. PMID: 24505130 Free PMC article.
The structural biology of CRISPR-Cas systems.
Jiang F, Doudna JA. Jiang F, et al. Curr Opin Struct Biol. 2015 Feb;30:100-111. doi: 10.1016/j.sbi.2015.02.002. Epub 2015 Feb 24. Curr Opin Struct Biol. 2015. PMID: 25723899 Free PMC article. Review.
CRISPR-Cas9 Structures and Mechanisms.
Jiang F, Doudna JA. Jiang F, et al. Annu Rev Biophys. 2017 May 22;46:505-529. doi: 10.1146/annurev-biophys-062215-010822. Epub 2017 Mar 30. Annu Rev Biophys. 2017. PMID: 28375731 Review.
Disabling Cas9 by an anti-CRISPR DNA mimic.
Shin J, Jiang F, Liu JJ, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA. Shin J, et al. Among authors: jiang f. Sci Adv. 2017 Jul 12;3(7):e1701620. doi: 10.1126/sciadv.1701620. eCollection 2017 Jul. Sci Adv. 2017. PMID: 28706995 Free PMC article.
Temperature-Responsive Competitive Inhibition of CRISPR-Cas9.
Jiang F, Liu JJ, Osuna BA, Xu M, Berry JD, Rauch BJ, Nogales E, Bondy-Denomy J, Doudna JA. Jiang F, et al. Mol Cell. 2019 Feb 7;73(3):601-610.e5. doi: 10.1016/j.molcel.2018.11.016. Epub 2018 Dec 27. Mol Cell. 2019. PMID: 30595438 Free PMC article.
Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair.
Lee K, Conboy M, Park HM, Jiang F, Kim HJ, Dewitt MA, Mackley VA, Chang K, Rao A, Skinner C, Shobha T, Mehdipour M, Liu H, Huang WC, Lan F, Bray NL, Li S, Corn JE, Kataoka K, Doudna JA, Conboy I, Murthy N. Lee K, et al. Among authors: jiang f. Nat Biomed Eng. 2017;1:889-901. doi: 10.1038/s41551-017-0137-2. Epub 2017 Oct 2. Nat Biomed Eng. 2017. PMID: 29805845 Free PMC article.
Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo.
Park HM, Liu H, Wu J, Chong A, Mackley V, Fellmann C, Rao A, Jiang F, Chu H, Murthy N, Lee K. Park HM, et al. Among authors: jiang f. Nat Commun. 2018 Aug 17;9(1):3313. doi: 10.1038/s41467-018-05641-3. Nat Commun. 2018. PMID: 30120228 Free PMC article.
6,570 results