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Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels.
Smith MR, Vayalil PK, Zhou F, Benavides GA, Beggs RR, Golzarian H, Nijampatnam B, Oliver PG, Smith RA, Murphy MP, Velu SE, Landar A. Smith MR, et al. Among authors: smith ra. Redox Biol. 2016 Aug;8:136-48. doi: 10.1016/j.redox.2016.01.002. Epub 2016 Jan 8. Redox Biol. 2016. PMID: 26774751 Free PMC article.
A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms.
Vayalil PK, Oh JY, Zhou F, Diers AR, Smith MR, Golzarian H, Oliver PG, Smith RA, Murphy MP, Velu SE, Landar A. Vayalil PK, et al. Among authors: smith ra, smith mr. PLoS One. 2015 Mar 18;10(3):e0120460. doi: 10.1371/journal.pone.0120460. eCollection 2015. PLoS One. 2015. PMID: 25785718 Free PMC article.
Detection of electrophile-sensitive proteins.
Wall SB, Smith MR, Ricart K, Zhou F, Vayalil PK, Oh JY, Landar A. Wall SB, et al. Among authors: smith mr. Biochim Biophys Acta. 2014 Feb;1840(2):913-22. doi: 10.1016/j.bbagen.2013.09.003. Epub 2013 Sep 8. Biochim Biophys Acta. 2014. PMID: 24021887 Free PMC article. Review.
Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry.
Krzywanski DM, Moellering DR, Westbrook DG, Dunham-Snary KJ, Brown J, Bray AW, Feeley KP, Sammy MJ, Smith MR, Schurr TG, Vita JA, Ambalavanan N, Calhoun D, Dell'Italia L, Ballinger SW. Krzywanski DM, et al. Among authors: smith mr. Circ Cardiovasc Genet. 2016 Feb;9(1):26-36. doi: 10.1161/CIRCGENETICS.115.001308. Epub 2016 Jan 19. Circ Cardiovasc Genet. 2016. PMID: 26787433 Free PMC article.
Darolutamide in Japanese patients with metastatic hormone-sensitive prostate cancer: Phase 3 ARASENS subgroup analysis.
Uemura M, Kikukawa H, Hashimoto Y, Uemura H, Mizokami A, Kato M, Matsushima H, Kosaka T, Nakamura M, Fukasawa S, Smith MR, Tombal B, Hussain M, Saad F, Fizazi K, Sternberg CN, Crawford ED, Kakiuchi H, Akiyama M, Li R, Kuss I, Joensuu H, Suzuki H. Uemura M, et al. Among authors: smith mr. Cancer Med. 2024 Nov;13(21):e70029. doi: 10.1002/cam4.70029. Cancer Med. 2024. PMID: 39527466 Free PMC article. Clinical Trial.
Untargeted metabolomics of 3xTg-AD neurotoxic astrocytes.
Carvalho D, Diaz-Amarilla P, Smith MR, Santi MD, Martinez-Busi M, Go YM, Jones DP, Duarte P, Savio E, Abin-Carriquiry JA, Arredondo F. Carvalho D, et al. Among authors: smith mr. J Proteomics. 2025 Jan 6;310:105336. doi: 10.1016/j.jprot.2024.105336. Epub 2024 Oct 23. J Proteomics. 2025. PMID: 39448026
1,168 results