Flower KJ - Search Results

1

DNA methylation profiling to assess pathogenicity of BRCA1 unclassified variants in breast cancer.

Flower KJ, Shenker NS, El-Bahrawy M, Goldgar DE, Parsons MT; KConFab Investigators; Affect Study Group; Spurdle AB, Morris JR, Brown R, Flanagan JM. Flower KJ, et al. Epigenetics. 2015;10(12):1121-32. doi: 10.1080/15592294.2015.1111504. Epigenetics. 2015. PMID: 26727311 Free PMC article.

2

Transcriptional implications of intragenic DNA methylation in the oestrogen receptor alpha gene in breast cancer cells and tissues.

Shenker NS, Flower KJ, Wilhelm-Benartzi CS, Dai W, Bell E, Gore E, El Bahrawy M, Weaver G, Brown R, Flanagan JM. Shenker NS, et al. Among authors: flower kj. BMC Cancer. 2015 May 1;15:337. doi: 10.1186/s12885-015-1335-5. BMC Cancer. 2015. PMID: 25927974 Free PMC article.

3

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis.

van Veldhoven K, Polidoro S, Baglietto L, Severi G, Sacerdote C, Panico S, Mattiello A, Palli D, Masala G, Krogh V, Agnoli C, Tumino R, Frasca G, Flower K, Curry E, Orr N, Tomczyk K, Jones ME, Ashworth A, Swerdlow A, Chadeau-Hyam M, Lund E, Garcia-Closas M, Sandanger TM, Flanagan JM, Vineis P. van Veldhoven K, et al. Clin Epigenetics. 2015 Aug 4;7(1):67. doi: 10.1186/s13148-015-0104-2. eCollection 2015. Clin Epigenetics. 2015. PMID: 26244061 Free PMC article.

4

Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer.

Flanagan JM, Wilson A, Koo C, Masrour N, Gallon J, Loomis E, Flower K, Wilhelm-Benartzi C, Hergovich A, Cunnea P, Gabra H, Braicu EI, Sehouli J, Darb-Esfahani S, Vanderstichele A, Vergote I, Kreuzinger C, Castillo-Tong DC, Wisman GBA, Berns EM, Siddiqui N, Paul J, Brown R. Flanagan JM, et al. Clin Cancer Res. 2017 May 1;23(9):2213-2222. doi: 10.1158/1078-0432.CCR-16-1754. Epub 2016 Sep 23. Clin Cancer Res. 2017. PMID: 27663594 Free article.

5

Loci-specific differences in blood DNA methylation in HBV-negative populations at risk for hepatocellular carcinoma development.

Lubecka K, Flower K, Beetch M, Qiu J, Kurzava L, Buvala H, Ruhayel A, Gawrieh S, Liangpunsakul S, Gonzalez T, McCabe G, Chalasani N, Flanagan JM, Stefanska B. Lubecka K, et al. Epigenetics. 2018;13(6):605-626. doi: 10.1080/15592294.2018.1481706. Epub 2018 Jul 30. Epigenetics. 2018. PMID: 29927686 Free PMC article.

6

Acceleration in the DNA methylation age in breast cancer tumours from very young women.

Oltra SS, Peña-Chilet M, Flower K, Martinez MT, Alonso E, Burgues O, Lluch A, Flanagan JM, Ribas G. Oltra SS, et al. Sci Rep. 2019 Oct 18;9(1):14991. doi: 10.1038/s41598-019-51457-6. Sci Rep. 2019. PMID: 31628391 Free PMC article.

7

Methylation deregulation of miRNA promoters identifies miR124-2 as a survival biomarker in Breast Cancer in very young women.

Oltra SS, Peña-Chilet M, Vidal-Tomas V, Flower K, Martinez MT, Alonso E, Burgues O, Lluch A, Flanagan JM, Ribas G. Oltra SS, et al. Sci Rep. 2018 Sep 26;8(1):14373. doi: 10.1038/s41598-018-32393-3. Sci Rep. 2018. PMID: 30258192 Free PMC article.

8

Is there a Role for Epigenetic Enhancement of Immunomodulatory Approaches to Cancer Treatment?

Flower KJ, Ghaem-Maghami S, Brown R. Flower KJ, et al. Curr Cancer Drug Targets. 2018;18(1):5-15. doi: 10.2174/1568009617666170206105131. Curr Cancer Drug Targets. 2018. PMID: 28176650 Free article. Review.

9

Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity.

Lubecka K, Kurzava L, Flower K, Buvala H, Zhang H, Teegarden D, Camarillo I, Suderman M, Kuang S, Andrisani O, Flanagan JM, Stefanska B. Lubecka K, et al. Carcinogenesis. 2016 Jul;37(7):656-68. doi: 10.1093/carcin/bgw048. Epub 2016 Apr 28. Carcinogenesis. 2016. PMID: 27207652 Free PMC article.

10

Stilbenoid-Mediated Epigenetic Activation of Semaphorin 3A in Breast Cancer Cells Involves Changes in Dynamic Interactions of DNA with DNMT3A and NF1C Transcription Factor.

Beetch M, Lubecka K, Shen K, Flower K, Harandi-Zadeh S, Suderman M, Flanagan JM, Stefanska B. Beetch M, et al. Mol Nutr Food Res. 2019 Oct;63(19):e1801386. doi: 10.1002/mnfr.201801386. Epub 2019 Jul 31. Mol Nutr Food Res. 2019. PMID: 31327173

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