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Cell-specific Dynamic Clamp analysis of the role of funny If current in cardiac pacemaking.
Ravagli E, Bucchi A, Bartolucci C, Paina M, Baruscotti M, DiFrancesco D, Severi S. Ravagli E, et al. Among authors: severi s. Prog Biophys Mol Biol. 2016 Jan;120(1-3):50-66. doi: 10.1016/j.pbiomolbio.2015.12.004. Epub 2015 Dec 21. Prog Biophys Mol Biol. 2016. PMID: 26718599
For this reason, we used a cell-specific approach, scaling the maximal conductance of the injected current based on the cell's spontaneous firing rate. The pacemaking rate, which was significantly reduced after application of Ivabradine, was restored by the injection of sy …
For this reason, we used a cell-specific approach, scaling the maximal conductance of the injected current based on the cell's sponta …
IKr Impact on Repolarization and Its Variability Assessed by Dynamic Clamp.
Altomare C, Bartolucci C, Sala L, Bernardi J, Mostacciuolo G, Rocchetti M, Severi S, Zaza A. Altomare C, et al. Among authors: severi s. Circ Arrhythm Electrophysiol. 2015 Oct;8(5):1265-75. doi: 10.1161/CIRCEP.114.002572. Epub 2015 Jun 23. Circ Arrhythm Electrophysiol. 2015. PMID: 26105569
D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence.
Moreno C, Oliveras A, Bartolucci C, Muñoz C, de la Cruz A, Peraza DA, Gimeno JR, Martín-Martínez M, Severi S, Felipe A, Lambiase PD, Gonzalez T, Valenzuela C. Moreno C, et al. Among authors: severi s. J Mol Cell Cardiol. 2017 Sep;110:61-69. doi: 10.1016/j.yjmcc.2017.07.009. Epub 2017 Jul 22. J Mol Cell Cardiol. 2017. PMID: 28739325 Free article.
The expression of the rare caveolin-3 variant T78M alters cardiac ion channels function and membrane excitability.
Campostrini G, Bonzanni M, Lissoni A, Bazzini C, Milanesi R, Vezzoli E, Francolini M, Baruscotti M, Bucchi A, Rivolta I, Fantini M, Severi S, Cappato R, Crotti L, J Schwartz P, DiFrancesco D, Barbuti A. Campostrini G, et al. Among authors: severi s. Cardiovasc Res. 2017 Aug 1;113(10):1256-1265. doi: 10.1093/cvr/cvx122. Cardiovasc Res. 2017. PMID: 28898996 Free PMC article.
310 results