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Luminal cysteine-proteases degrade colonic tight junction structure and are responsible for abdominal pain in constipation-predominant IBS.
Annaházi A, Ferrier L, Bézirard V, Lévêque M, Eutamène H, Ait-Belgnaoui A, Coëffier M, Ducrotté P, Róka R, Inczefi O, Gecse K, Rosztóczy A, Molnár T, Ringel-Kulka T, Ringel Y, Piche T, Theodorou V, Wittmann T, Bueno L. Annaházi A, et al. Am J Gastroenterol. 2013 Aug;108(8):1322-31. doi: 10.1038/ajg.2013.152. Epub 2013 May 28. Am J Gastroenterol. 2013. PMID: 23711626
38 results