Bontjer I - Search Results

1

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.

de Taeye SW, Ozorowski G, Torrents de la Peña A, Guttman M, Julien JP, van den Kerkhof TL, Burger JA, Pritchard LK, Pugach P, Yasmeen A, Crampton J, Hu J, Bontjer I, Torres JL, Arendt H, DeStefano J, Koff WC, Schuitemaker H, Eggink D, Berkhout B, Dean H, LaBranche C, Crotty S, Crispin M, Montefiori DC, Klasse PJ, Lee KK, Moore JP, Wilson IA, Ward AB, Sanders RW. de Taeye SW, et al. Among authors: bontjer i. Cell. 2015 Dec 17;163(7):1702-15. doi: 10.1016/j.cell.2015.11.056. Cell. 2015. PMID: 26687358 Free PMC article.

2

The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion.

Sanders RW, van Anken E, Nabatov AA, Liscaljet IM, Bontjer I, Eggink D, Melchers M, Busser E, Dankers MM, Groot F, Braakman I, Berkhout B, Paxton WA. Sanders RW, et al. Among authors: bontjer i. Retrovirology. 2008 Jan 31;5:10. doi: 10.1186/1742-4690-5-10. Retrovirology. 2008. PMID: 18237398 Free PMC article.

3

Only five of 10 strictly conserved disulfide bonds are essential for folding and eight for function of the HIV-1 envelope glycoprotein.

van Anken E, Sanders RW, Liscaljet IM, Land A, Bontjer I, Tillemans S, Nabatov AA, Paxton WA, Berkhout B, Braakman I. van Anken E, et al. Among authors: bontjer i. Mol Biol Cell. 2008 Oct;19(10):4298-309. doi: 10.1091/mbc.e07-12-1282. Epub 2008 Jul 23. Mol Biol Cell. 2008. PMID: 18653472 Free PMC article.

4

Evolution rescues folding of human immunodeficiency virus-1 envelope glycoprotein GP120 lacking a conserved disulfide bond.

Sanders RW, Hsu ST, van Anken E, Liscaljet IM, Dankers M, Bontjer I, Land A, Braakman I, Bonvin AM, Berkhout B. Sanders RW, et al. Among authors: bontjer i. Mol Biol Cell. 2008 Nov;19(11):4707-16. doi: 10.1091/mbc.e08-07-0670. Epub 2008 Aug 27. Mol Biol Cell. 2008. PMID: 18753405 Free PMC article.

5

Optimization of human immunodeficiency virus type 1 envelope glycoproteins with V1/V2 deleted, using virus evolution.

Bontjer I, Land A, Eggink D, Verkade E, Tuin K, Baldwin C, Pollakis G, Paxton WA, Braakman I, Berkhout B, Sanders RW. Bontjer I, et al. J Virol. 2009 Jan;83(1):368-83. doi: 10.1128/JVI.01404-08. Epub 2008 Oct 15. J Virol. 2009. PMID: 18922866 Free PMC article.

6

Stabilized HIV-1 envelope glycoprotein trimers lacking the V1V2 domain, obtained by virus evolution.

Bontjer I, Melchers M, Eggink D, David K, Moore JP, Berkhout B, Sanders RW. Bontjer I, et al. J Biol Chem. 2010 Nov 19;285(47):36456-70. doi: 10.1074/jbc.M110.156588. Epub 2010 Sep 8. J Biol Chem. 2010. PMID: 20826824 Free PMC article.

The design of the trimers was guided by HIV-1 evolution studies that identified compensatory changes in V1V2-deleted but functional Env proteins (Bontjer, I., Land, A., Eggink, D., Verkade, E., Tuin, K., Baldwin, C., Pollakis, G., Paxton, W. A., Braakman, I., …

The design of the trimers was guided by HIV-1 evolution studies that identified compensatory changes in V1V2-deleted but functional Env prot …

7

A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells.

Melchers M, Matthews K, de Vries RP, Eggink D, van Montfort T, Bontjer I, van de Sandt C, David K, Berkhout B, Moore JP, Sanders RW. Melchers M, et al. Among authors: bontjer i. Retrovirology. 2011 Jun 20;8:48. doi: 10.1186/1742-4690-8-48. Retrovirology. 2011. PMID: 21689404 Free PMC article.

8

Resistance of human immunodeficiency virus type 1 to a third-generation fusion inhibitor requires multiple mutations in gp41 and is accompanied by a dramatic loss of gp41 function.

Eggink D, Bontjer I, Langedijk JP, Berkhout B, Sanders RW. Eggink D, et al. Among authors: bontjer i. J Virol. 2011 Oct;85(20):10785-97. doi: 10.1128/JVI.05331-11. Epub 2011 Aug 10. J Virol. 2011. PMID: 21835789 Free PMC article.

9

Targeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responses.

Melchers M, Bontjer I, Tong T, Chung NP, Klasse PJ, Eggink D, Montefiori DC, Gentile M, Cerutti A, Olson WC, Berkhout B, Binley JM, Moore JP, Sanders RW. Melchers M, et al. Among authors: bontjer i. J Virol. 2012 Mar;86(5):2488-500. doi: 10.1128/JVI.06259-11. Epub 2011 Dec 28. J Virol. 2012. PMID: 22205734 Free PMC article.

10

Comparative Immunogenicity of Evolved V1V2-Deleted HIV-1 Envelope Glycoprotein Trimers.

Bontjer I, Melchers M, Tong T, van Montfort T, Eggink D, Montefiori D, Olson WC, Moore JP, Binley JM, Berkhout B, Sanders RW. Bontjer I, et al. PLoS One. 2013 Jun 26;8(6):e67484. doi: 10.1371/journal.pone.0067484. Print 2013. PLoS One. 2013. PMID: 23840716 Free PMC article.

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