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Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis.
Laky K, Kinard JL, Li JM, Moore IN, Lack J, Fischer ER, Kabat J, Latanich R, Zachos NC, Limkar AR, Weissler KA, Thompson RW, Wynn TA, Dietz HC, Guerrerio AL, Frischmeyer-Guerrerio PA. Laky K, et al. Among authors: zachos nc. Sci Immunol. 2023 Jan 6;8(79):eabp9940. doi: 10.1126/sciimmunol.abp9940. Epub 2023 Jan 6. Sci Immunol. 2023. PMID: 36608150 Free PMC article.
Molecular physiology of intestinal Na+/H+ exchange.
Zachos NC, Tse M, Donowitz M. Zachos NC, et al. Annu Rev Physiol. 2005;67:411-43. doi: 10.1146/annurev.physiol.67.031103.153004. Annu Rev Physiol. 2005. PMID: 15709964 Review.
NHERF family and NHE3 regulation.
Donowitz M, Cha B, Zachos NC, Brett CL, Sharma A, Tse CM, Li X. Donowitz M, et al. Among authors: zachos nc. J Physiol. 2005 Aug 15;567(Pt 1):3-11. doi: 10.1113/jphysiol.2005.090399. Epub 2005 May 19. J Physiol. 2005. PMID: 15905209 Free PMC article. Review.
Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule.
Murtazina R, Kovbasnjuk O, Zachos NC, Li X, Chen Y, Hubbard A, Hogema BM, Steplock D, Seidler U, Hoque KM, Tse CM, De Jonge HR, Weinman EJ, Donowitz M. Murtazina R, et al. Among authors: zachos nc. J Biol Chem. 2007 Aug 24;282(34):25141-51. doi: 10.1074/jbc.M701910200. Epub 2007 Jun 19. J Biol Chem. 2007. PMID: 17580307 Free article.
Proteome of murine jejunal brush border membrane vesicles.
Donowitz M, Singh S, Salahuddin FF, Hogema BM, Chen Y, Gucek M, Cole RN, Ham A, Zachos NC, Kovbasnjuk O, Lapierre LA, Broere N, Goldenring J, deJonge H, Li X. Donowitz M, et al. Among authors: zachos nc. J Proteome Res. 2007 Oct;6(10):4068-79. doi: 10.1021/pr0701761. Epub 2007 Sep 11. J Proteome Res. 2007. PMID: 17845021
Downregulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrhea.
Sullivan S, Alex P, Dassopoulos T, Zachos NC, Iacobuzio-Donahue C, Donowitz M, Brant SR, Cuffari C, Harris ML, Datta LW, Conklin L, Chen Y, Li X. Sullivan S, et al. Among authors: zachos nc. Inflamm Bowel Dis. 2009 Feb;15(2):261-74. doi: 10.1002/ibd.20743. Inflamm Bowel Dis. 2009. PMID: 18942765 Free PMC article.
NHE3 regulatory complexes.
Donowitz M, Mohan S, Zhu CX, Chen TE, Lin R, Cha B, Zachos NC, Murtazina R, Sarker R, Li X. Donowitz M, et al. Among authors: zachos nc. J Exp Biol. 2009 Jun;212(Pt 11):1638-46. doi: 10.1242/jeb.028605. J Exp Biol. 2009. PMID: 19448074 Free PMC article. Review.
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