Kostenis E - Search Results

1

N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators.

Blöcher R, Lamers C, Wittmann SK, Merk D, Hartmann M, Weizel L, Diehl O, Brüggerhoff A, Boß M, Kaiser A, Schader T, Göbel T, Grundmann M, Angioni C, Heering J, Geisslinger G, Wurglics M, Kostenis E, Brüne B, Steinhilber D, Schubert-Zsilavecz M, Kahnt AS, Proschak E. Blöcher R, et al. Among authors: kostenis e. J Med Chem. 2016 Jan 14;59(1):61-81. doi: 10.1021/acs.jmedchem.5b01239. Epub 2015 Dec 25. J Med Chem. 2016. PMID: 26595749

2

Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors.

Botero Cid MH, Holzgrabe U, Kostenis E, Mohr K, Tränkle C. Botero Cid MH, et al. Among authors: kostenis e. J Med Chem. 1994 May 13;37(10):1439-45. doi: 10.1021/jm00036a008. J Med Chem. 1994. PMID: 8182702

3

Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: search for the minimum essential distances between the pharmacophoric elements.

Nassif-Makki T, Tränkle C, Zlotos D, Bejeuhr G, Cambareri A, Pfletschinger C, Kostenis E, Mohr K, Holzgrabe U. Nassif-Makki T, et al. Among authors: kostenis e. J Med Chem. 1999 Mar 11;42(5):849-58. doi: 10.1021/jm981023f. J Med Chem. 1999. PMID: 10072682

4

Structure-activity relationships in a series of bisquaternary bisphthalimidine derivatives modulating the muscarinic M(2)-receptor allosterically.

Botero Cid HM, Tränkle C, Baumann K, Pick R, Mies-Klomfass E, Kostenis E, Mohr K, Holzgrabe U. Botero Cid HM, et al. Among authors: kostenis e. J Med Chem. 2000 Jun 1;43(11):2155-64. doi: 10.1021/jm991136e. J Med Chem. 2000. PMID: 10841794

5

Identification of nonpeptidic urotensin II receptor antagonists by virtual screening based on a pharmacophore model derived from structure-activity relationships and nuclear magnetic resonance studies on urotensin II.

Flohr S, Kurz M, Kostenis E, Brkovich A, Fournier A, Klabunde T. Flohr S, et al. Among authors: kostenis e. J Med Chem. 2002 Apr 25;45(9):1799-805. doi: 10.1021/jm0111043. J Med Chem. 2002. PMID: 11960491

6

Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes.

Christiansen E, Urban C, Merten N, Liebscher K, Karlsen KK, Hamacher A, Spinrath A, Bond AD, Drewke C, Ullrich S, Kassack MU, Kostenis E, Ulven T. Christiansen E, et al. Among authors: kostenis e. J Med Chem. 2008 Nov 27;51(22):7061-4. doi: 10.1021/jm8010178. J Med Chem. 2008. PMID: 18947221

7

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.

Schmidt J, Smith NJ, Christiansen E, Tikhonova IG, Grundmann M, Hudson BD, Ward RJ, Drewke C, Milligan G, Kostenis E, Ulven T. Schmidt J, et al. Among authors: kostenis e. J Biol Chem. 2011 Mar 25;286(12):10628-40. doi: 10.1074/jbc.M110.210872. Epub 2011 Jan 10. J Biol Chem. 2011. PMID: 21220428 Free PMC article.

8

Conjugated linoleic acids mediate insulin release through islet G protein-coupled receptor FFA1/GPR40.

Schmidt J, Liebscher K, Merten N, Grundmann M, Mielenz M, Sauerwein H, Christiansen E, Due-Hansen ME, Ulven T, Ullrich S, Gomeza J, Drewke C, Kostenis E. Schmidt J, et al. Among authors: kostenis e. J Biol Chem. 2011 Apr 8;286(14):11890-4. doi: 10.1074/jbc.C110.200477. Epub 2011 Feb 21. J Biol Chem. 2011. PMID: 21339298 Free PMC article.

9

Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties.

Christiansen E, Urban C, Grundmann M, Due-Hansen ME, Hagesaether E, Schmidt J, Pardo L, Ullrich S, Kostenis E, Kassack M, Ulven T. Christiansen E, et al. Among authors: kostenis e. J Med Chem. 2011 Oct 13;54(19):6691-703. doi: 10.1021/jm2005699. Epub 2011 Sep 13. J Med Chem. 2011. PMID: 21854074

10

Applying label-free dynamic mass redistribution technology to frame signaling of G protein-coupled receptors noninvasively in living cells.

Schröder R, Schmidt J, Blättermann S, Peters L, Janssen N, Grundmann M, Seemann W, Kaufel D, Merten N, Drewke C, Gomeza J, Milligan G, Mohr K, Kostenis E. Schröder R, et al. Among authors: kostenis e. Nat Protoc. 2011 Oct 20;6(11):1748-60. doi: 10.1038/nprot.2011.386. Nat Protoc. 2011. PMID: 22015845

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