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Page 1
Meta-analysis identifies seven susceptibility loci involved in the atopic march.
Marenholz I, Esparza-Gordillo J, Rüschendorf F, Bauerfeind A, Strachan DP, Spycher BD, Baurecht H, Margaritte-Jeannin P, Sääf A, Kerkhof M, Ege M, Baltic S, Matheson MC, Li J, Michel S, Ang WQ, McArdle W, Arnold A, Homuth G, Demenais F, Bouzigon E, Söderhäll C, Pershagen G, de Jongste JC, Postma DS, Braun-Fahrländer C, Horak E, Ogorodova LM, Puzyrev VP, Bragina EY, Hudson TJ, Morin C, Duffy DL, Marks GB, Robertson CF, Montgomery GW, Musk B, Thompson PJ, Martin NG, James A, Sleiman P, Toskala E, Rodriguez E, Fölster-Holst R, Franke A, Lieb W, Gieger C, Heinzmann A, Rietschel E, Keil T, Cichon S, Nöthen MM, Pennell CE, Sly PD, Schmidt CO, Matanovic A, Schneider V, Heinig M, Hübner N, Holt PG, Lau S, Kabesch M, Weidinger S, Hakonarson H, Ferreira MAR, Laprise C, Freidin MB, Genuneit J, Koppelman GH, Melén E, Dizier MH, Henderson AJ, Lee YA. Marenholz I, et al. Among authors: rietschel e. Nat Commun. 2015 Nov 6;6:8804. doi: 10.1038/ncomms9804. Nat Commun. 2015. PMID: 26542096 Free PMC article.
Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages.
Schieck M, Schouten JP, Michel S, Suttner K, Toncheva AA, Gaertner VD, Illig T, Lipinski S, Franke A, Klintschar M, Kalayci O, Sahiner UM, Birben E, Melén E, Pershagen G, Freidin MB, Ogorodova LM, Granell R, Henderson J, Brunekreef B, Smit HA, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Genuneit J, Jonigk D, Postma DS, Koppelman GH, Vonk JM, Timens W, Boezen HM, Kabesch M. Schieck M, et al. Among authors: rietschel e. J Allergy Clin Immunol. 2016 Aug;138(2):421-31. doi: 10.1016/j.jaci.2015.12.1305. Epub 2016 Feb 20. J Allergy Clin Immunol. 2016. PMID: 26906082
Fine-mapping of IgE-associated loci 1q23, 5q31, and 12q13 using 1000 Genomes Project data.
Sharma V, Michel S, Gaertner V, Franke A, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Frischer T, Genuneit J, Zeilinger S, Illig T, Schedel M, Potaczek DP, Kabesch M. Sharma V, et al. Among authors: rietschel e. Allergy. 2014 Aug;69(8):1077-84. doi: 10.1111/all.12431. Epub 2014 Jun 14. Allergy. 2014. PMID: 24930997
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.
Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, Heinzmann A, Simma B, Frischer T, Willis-Owen SA, Wong KC, Illig T, Vogelberg C, Weiland SK, von Mutius E, Abecasis GR, Farrall M, Gut IG, Lathrop GM, Cookson WO. Moffatt MF, et al. Among authors: rietschel e. Nature. 2007 Jul 26;448(7152):470-3. doi: 10.1038/nature06014. Epub 2007 Jul 4. Nature. 2007. PMID: 17611496 Free article.
Unifying candidate gene and GWAS Approaches in Asthma.
Michel S, Liang L, Depner M, Klopp N, Ruether A, Kumar A, Schedel M, Vogelberg C, von Mutius E, von Berg A, Bufe A, Rietschel E, Heinzmann A, Laub O, Simma B, Frischer T, Genuneit J, Gut IG, Schreiber S, Lathrop M, Illig T, Kabesch M. Michel S, et al. Among authors: rietschel e. PLoS One. 2010 Nov 12;5(11):e13894. doi: 10.1371/journal.pone.0013894. PLoS One. 2010. PMID: 21103062 Free PMC article.
Different FCER1A polymorphisms influence IgE levels in asthmatics and non-asthmatics.
Potaczek DP, Michel S, Sharma V, Zeilinger S, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Frischer T, Genuneit J, Illig T, Kabesch M. Potaczek DP, et al. Among authors: rietschel e. Pediatr Allergy Immunol. 2013 Aug;24(5):441-9. doi: 10.1111/pai.12083. Epub 2013 Jun 3. Pediatr Allergy Immunol. 2013. PMID: 23725541
Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels.
Schedel M, Michel S, Gaertner VD, Toncheva AA, Depner M, Binia A, Schieck M, Rieger MT, Klopp N, von Berg A, Bufe A, Laub O, Rietschel E, Heinzmann A, Simma B, Vogelberg C, Genuneit J, Illig T, Kabesch M. Schedel M, et al. Among authors: rietschel e. J Allergy Clin Immunol. 2015 Oct;136(4):893-903.e14. doi: 10.1016/j.jaci.2015.03.014. Epub 2015 Apr 28. J Allergy Clin Immunol. 2015. PMID: 25930191
Nocturnal asthma is affected by genetic interactions between RORA and NPSR1.
Gaertner VD, Michel S, Curtin JA, Pulkkinen V, Acevedo N, Söderhäll C, von Berg A, Bufe A, Laub O, Rietschel E, Heinzmann A, Simma B, Vogelberg C, Pershagen G, Melén E, Simpson A, Custovic A, Kere J, Kabesch M. Gaertner VD, et al. Among authors: rietschel e. Pediatr Pulmonol. 2019 Jun;54(6):847-857. doi: 10.1002/ppul.24292. Epub 2019 Mar 29. Pediatr Pulmonol. 2019. PMID: 30927345
Genetic variants in Protocadherin-1, bronchial hyper-responsiveness, and asthma subphenotypes in German children.
Toncheva AA, Suttner K, Michel S, Klopp N, Illig T, Balschun T, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Frischer T, Genuneit J, von Mutius E, Kabesch M. Toncheva AA, et al. Among authors: rietschel e. Pediatr Allergy Immunol. 2012 Nov;23(7):636-41. doi: 10.1111/j.1399-3038.2012.01334.x. Epub 2012 Oct 11. Pediatr Allergy Immunol. 2012. PMID: 23050600
Genetic variation in TH17 pathway genes, childhood asthma, and total serum IgE levels.
Schieck M, Michel S, Suttner K, Illig T, Zeilinger S, Franke A, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Frischer T, Genuneit J, Kerzel S, Kabesch M. Schieck M, et al. Among authors: rietschel e. J Allergy Clin Immunol. 2014 Mar;133(3):888-91. doi: 10.1016/j.jaci.2013.08.048. Epub 2013 Nov 1. J Allergy Clin Immunol. 2014. PMID: 24184148 No abstract available.
325 results