Maxson JE - Search Results

1

The Colony-Stimulating Factor 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK Inhibition, and Mimics T618I.

Maxson JE, Luty SB, MacManiman JD, Paik JC, Gotlib J, Greenberg P, Bahamadi S, Savage SL, Abel ML, Eide CA, Loriaux MM, Stevens EA, Tyner JW. Maxson JE, et al. Clin Cancer Res. 2016 Feb 1;22(3):757-64. doi: 10.1158/1078-0432.CCR-14-3100. Epub 2015 Oct 16. Clin Cancer Res. 2016. PMID: 26475333 Free PMC article.

2

CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia.

Pardanani A, Lasho TL, Laborde RR, Elliott M, Hanson CA, Knudson RA, Ketterling RP, Maxson JE, Tyner JW, Tefferi A. Pardanani A, et al. Among authors: maxson je. Leukemia. 2013 Sep;27(9):1870-3. doi: 10.1038/leu.2013.122. Epub 2013 Apr 22. Leukemia. 2013. PMID: 23604229 Free PMC article.

3

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML.

Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, Bottomly D, Wilmot B, McWeeney SK, Tognon CE, Pond JB, Collins RH, Goueli B, Oh ST, Deininger MW, Chang BH, Loriaux MM, Druker BJ, Tyner JW. Maxson JE, et al. N Engl J Med. 2013 May 9;368(19):1781-90. doi: 10.1056/NEJMoa1214514. N Engl J Med. 2013. PMID: 23656643 Free PMC article.

4

The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment.

Gotlib J, Maxson JE, George TI, Tyner JW. Gotlib J, et al. Among authors: maxson je. Blood. 2013 Sep 5;122(10):1707-11. doi: 10.1182/blood-2013-05-500959. Epub 2013 Jul 29. Blood. 2013. PMID: 23896413 Free PMC article. Review.

5

The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition.

Fleischman AG, Maxson JE, Luty SB, Agarwal A, Royer LR, Abel ML, MacManiman JD, Loriaux MM, Druker BJ, Tyner JW. Fleischman AG, et al. Among authors: maxson je. Blood. 2013 Nov 21;122(22):3628-31. doi: 10.1182/blood-2013-06-509976. Epub 2013 Sep 30. Blood. 2013. PMID: 24081659 Free PMC article.

6

Ligand independence of the T618I mutation in the colony-stimulating factor 3 receptor (CSF3R) protein results from loss of O-linked glycosylation and increased receptor dimerization.

Maxson JE, Luty SB, MacManiman JD, Abel ML, Druker BJ, Tyner JW. Maxson JE, et al. J Biol Chem. 2014 Feb 28;289(9):5820-7. doi: 10.1074/jbc.M113.508440. Epub 2014 Jan 8. J Biol Chem. 2014. PMID: 24403076 Free PMC article.

7

Significant clinical response to JAK1/2 inhibition in a patient with CSF3R-T618I-positive atypical chronic myeloid leukemia.

Dao KH, Solti MB, Maxson JE, Winton EF, Press RD, Druker BJ, Tyner JW. Dao KH, et al. Among authors: maxson je. Leuk Res Rep. 2014 Aug 1;3(2):67-9. doi: 10.1016/j.lrr.2014.07.002. eCollection 2014. Leuk Res Rep. 2014. PMID: 25180155 Free PMC article.

8

Therapeutically Targetable ALK Mutations in Leukemia.

Maxson JE, Davare MA, Luty SB, Eide CA, Chang BH, Loriaux MM, Tognon CE, Bottomly D, Wilmot B, McWeeney SK, Druker BJ, Tyner JW. Maxson JE, et al. Cancer Res. 2015 Jun 1;75(11):2146-50. doi: 10.1158/0008-5472.CAN-14-1576. Cancer Res. 2015. PMID: 26032424 Free PMC article.

9

Clonality of neutrophilia associated with plasma cell neoplasms: report of a SETBP1 mutation and analysis of a single institution series.

Stevens B, Maxson J, Tyner J, Smith CA, Gutman JA, Robinson W, Jordan CT, Lee CK, Swisshelm K, Tobin J, Wei Q, Schowinsky J, Rinella S, Lee HG, Pollyea DA. Stevens B, et al. Leuk Lymphoma. 2016;57(4):927-34. doi: 10.3109/10428194.2015.1094697. Epub 2015 Oct 27. Leuk Lymphoma. 2016. PMID: 26389776 Free PMC article.

10

Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis.

Maxson JE, Abel ML, Wang J, Deng X, Reckel S, Luty SB, Sun H, Gorenstein J, Hughes SB, Bottomly D, Wilmot B, McWeeney SK, Radich J, Hantschel O, Middleton RE, Gray NS, Druker BJ, Tyner JW. Maxson JE, et al. Cancer Res. 2016 Jan 1;76(1):127-38. doi: 10.1158/0008-5472.CAN-15-0817. Epub 2015 Dec 17. Cancer Res. 2016. PMID: 26677978 Free PMC article.

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