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Loss of BAP1 function leads to EZH2-dependent transformation.
LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller MD, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, Shi X, Doud EH, Krivtsov AV, Chung YR, Khodos I, de Stanchina E, Ouerfelli O, Adusumilli PS, Thomas PM, Kelleher NL, Luo M, Keilhack H, Abdel-Wahab O, Melnick A, Armstrong SA, Levine RL. LaFave LM, et al. Among authors: blum g. Nat Med. 2015 Nov;21(11):1344-9. doi: 10.1038/nm.3947. Epub 2015 Oct 5. Nat Med. 2015. PMID: 26437366 Free PMC article.
Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status".
LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller MD, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, Shi X, Doud EH, Krivtsov AV, Chung YR, Khodos I, de Stanchina E, Ouerfelli O, Adusumilli PS, Thomas PM, Kelleher NL, Luo M, Keilhack H, Abdel-Wahab O, Melnick A, Armstrong SA, Levine RL. LaFave LM, et al. Among authors: blum g. Nat Med. 2016 Jun 7;22(6):578-9. doi: 10.1038/nm.4094. Nat Med. 2016. PMID: 27270773 No abstract available.
Small-molecule inhibitors of SETD8 with cellular activity.
Blum G, Ibáñez G, Rao X, Shum D, Radu C, Djaballah H, Rice JC, Luo M. Blum G, et al. ACS Chem Biol. 2014 Nov 21;9(11):2471-8. doi: 10.1021/cb500515r. Epub 2014 Sep 3. ACS Chem Biol. 2014. PMID: 25137013 Free PMC article.
185 results