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Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.
Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE. Ferdaoussi M, et al. Among authors: kibbey rg. J Clin Invest. 2015 Oct 1;125(10):3847-60. doi: 10.1172/JCI82498. Epub 2015 Sep 21. J Clin Invest. 2015. PMID: 26389676 Free PMC article.
Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels.
Taddeo EP, Alsabeeh N, Baghdasarian S, Wikstrom JD, Ritou E, Sereda S, Erion K, Li J, Stiles L, Abdulla M, Swanson Z, Wilhelm JJ, Bellin MD, Kibbey RG, Liesa M, Shirihai OS. Taddeo EP, et al. Among authors: kibbey rg. Diabetes. 2020 Feb;69(2):131-145. doi: 10.2337/db19-0379. Epub 2019 Nov 18. Diabetes. 2020. PMID: 31740442 Free PMC article.
Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle.
Alves TC, Pongratz RL, Zhao X, Yarborough O, Sereda S, Shirihai O, Cline GW, Mason G, Kibbey RG. Alves TC, et al. Among authors: kibbey rg. Cell Metab. 2015 Nov 3;22(5):936-47. doi: 10.1016/j.cmet.2015.08.021. Epub 2015 Sep 24. Cell Metab. 2015. PMID: 26411341 Free PMC article.
Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma.
Chung KM, Singh J, Lawres L, Dorans KJ, Garcia C, Burkhardt DB, Robbins R, Bhutkar A, Cardone R, Zhao X, Babic A, Vayrynen SA, Dias Costa A, Nowak JA, Chang DT, Dunne RF, Hezel AF, Koong AC, Wilhelm JJ, Bellin MD, Nylander V, Gloyn AL, McCarthy MI, Kibbey RG, Krishnaswamy S, Wolpin BM, Jacks T, Fuchs CS, Muzumdar MD. Chung KM, et al. Among authors: kibbey rg. Cell. 2020 May 14;181(4):832-847.e18. doi: 10.1016/j.cell.2020.03.062. Epub 2020 Apr 17. Cell. 2020. PMID: 32304665 Free PMC article.
Metabolic cycles and signals for insulin secretion.
Merrins MJ, Corkey BE, Kibbey RG, Prentki M. Merrins MJ, et al. Among authors: kibbey rg. Cell Metab. 2022 Jul 5;34(7):947-968. doi: 10.1016/j.cmet.2022.06.003. Epub 2022 Jun 20. Cell Metab. 2022. PMID: 35728586 Free PMC article. Review.
Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.
Pongratz RL, Kibbey RG, Kirkpatrick CL, Zhao X, Pontoglio M, Yaniv M, Wollheim CB, Shulman GI, Cline GW. Pongratz RL, et al. Among authors: kibbey rg. J Biol Chem. 2009 Jun 19;284(25):16808-16821. doi: 10.1074/jbc.M807723200. Epub 2009 Apr 17. J Biol Chem. 2009. PMID: 19376774 Free PMC article.
69 results