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The spliceosome is a therapeutic vulnerability in MYC-driven cancer.
Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, Bernardi RJ, Skinner SO, Jain A, Orellana M, Lagisetti C, Golding I, Jung SY, Neilson JR, Zhang XH, Cooper TA, Webb TR, Neel BG, Shaw CA, Westbrook TF. Hsu TY, et al. Among authors: skinner so. Nature. 2015 Sep 17;525(7569):384-8. doi: 10.1038/nature14985. Epub 2015 Sep 2. Nature. 2015. PMID: 26331541 Free PMC article.
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.
Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TF. Kessler JD, et al. Among authors: skinner so. Science. 2012 Jan 20;335(6066):348-53. doi: 10.1126/science.1212728. Epub 2011 Dec 8. Science. 2012. PMID: 22157079 Free PMC article.
Stochastic Kinetics of Nascent RNA.
Xu H, Skinner SO, Sokac AM, Golding I. Xu H, et al. Among authors: skinner so. Phys Rev Lett. 2016 Sep 16;117(12):128101. doi: 10.1103/PhysRevLett.117.128101. Epub 2016 Sep 13. Phys Rev Lett. 2016. PMID: 27667861 Free PMC article.
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