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Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.
Alánová P, Husková Z, Kopkan L, Sporková A, Jíchová Š, Neckář J, Imig JD, Klevstig M, Kolář F, Rami Reddy N, Falck JR, Sadowski J, Nishiyama A, Kramer HJ, Melenovský V, Červenková L, Kujal P, Vernerová Z, Červenka L. Alánová P, et al. Among authors: klevstig m. Vascul Pharmacol. 2015 Oct;73:45-56. doi: 10.1016/j.vph.2015.08.013. Epub 2015 Aug 22. Vascul Pharmacol. 2015. PMID: 26304700
CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis.
Neckář J, Šilhavy J, Zídek V, Landa V, Mlejnek P, Šimáková M, Seidman JG, Seidman C, Kazdová L, Klevstig M, Novák F, Vecka M, Papoušek F, Houštěk J, Drahota Z, Kurtz TW, Kolář F, Pravenec M. Neckář J, et al. Among authors: klevstig m. Physiol Genomics. 2012 Feb 1;44(2):173-82. doi: 10.1152/physiolgenomics.00083.2011. Epub 2011 Nov 29. Physiol Genomics. 2012. PMID: 22128087 Free PMC article.
Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart.
Mardani I, Tomas Dalen K, Drevinge C, Miljanovic A, Ståhlman M, Klevstig M, Scharin Täng M, Fogelstrand P, Levin M, Ekstrand M, Nair S, Redfors B, Omerovic E, Andersson L, Kimmel AR, Borén J, Levin MC. Mardani I, et al. Among authors: klevstig m. Sci Rep. 2019 May 6;9(1):6909. doi: 10.1038/s41598-019-43335-y. Sci Rep. 2019. PMID: 31061399 Free PMC article.
Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts.
Andersson L, Drevinge C, Mardani I, Dalen KT, Ståhlman M, Klevstig M, Lundqvist A, Haugen F, Adiels M, Fogelstrand P, Asin-Cayuela J, Hultén LM, Levin M, Ehrenborg E, Lee YK, Kimmel AR, Borén J, Levin MC. Andersson L, et al. Among authors: klevstig m. Int J Biochem Cell Biol. 2017 Oct;91(Pt A):9-13. doi: 10.1016/j.biocel.2017.07.021. Epub 2017 Aug 12. Int J Biochem Cell Biol. 2017. PMID: 28811250
Perilipin 5 is protective in the ischemic heart.
Drevinge C, Dalen KT, Mannila MN, Täng MS, Ståhlman M, Klevstig M, Lundqvist A, Mardani I, Haugen F, Fogelstrand P, Adiels M, Asin-Cayuela J, Ekestam C, Gådin JR, Lee YK, Nebb H, Svedlund S, Johansson BR, Hultén LM, Romeo S, Redfors B, Omerovic E, Levin M, Gan LM, Eriksson P, Andersson L, Ehrenborg E, Kimmel AR, Borén J, Levin MC. Drevinge C, et al. Among authors: klevstig m. Int J Cardiol. 2016 Sep 15;219:446-54. doi: 10.1016/j.ijcard.2016.06.037. Epub 2016 Jun 16. Int J Cardiol. 2016. PMID: 27376234 Free article.
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