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Page 1
Template-assisted covalent modification underlies activity of covalent molecular glues.
Li YD, Ma MW, Hassan MM, Hunkeler M, Teng M, Puvar K, Rutter JC, Lumpkin RJ, Sandoval B, Jin CY, Schmoker AM, Ficarro SB, Cheong H, Metivier RJ, Wang MY, Xu S, Byun WS, Groendyke BJ, You I, Sigua LH, Tavares I, Zou C, Tsai JM, Park PMC, Yoon H, Majewski FC, Sperling HT, Marto JA, Qi J, Nowak RP, Donovan KA, Słabicki M, Gray NS, Fischer ES, Ebert BL. Li YD, et al. Among authors: nowak rp. Nat Chem Biol. 2024 Jul 29. doi: 10.1038/s41589-024-01668-4. Online ahead of print. Nat Chem Biol. 2024. PMID: 39075252
Polymerization of ZBTB transcription factors regulates chromatin occupancy.
Park PMC, Park J, Brown J, Hunkeler M, Roy Burman SS, Donovan KA, Yoon H, Nowak RP, Słabicki M, Ebert BL, Fischer ES. Park PMC, et al. Among authors: nowak rp. Mol Cell. 2024 Jul 11;84(13):2511-2524.e8. doi: 10.1016/j.molcel.2024.06.010. Mol Cell. 2024. PMID: 38996460
A double whammy for KEAP1.
Gerhartz J, Nowak RP. Gerhartz J, et al. Among authors: nowak rp. Cell Chem Biol. 2024 Jun 20;31(6):1047-1049. doi: 10.1016/j.chembiol.2024.05.014. Cell Chem Biol. 2024. PMID: 38906110
Targeted protein degradation: from mechanisms to clinic.
Tsai JM, Nowak RP, Ebert BL, Fischer ES. Tsai JM, et al. Among authors: nowak rp. Nat Rev Mol Cell Biol. 2024 Sep;25(9):740-757. doi: 10.1038/s41580-024-00729-9. Epub 2024 Apr 29. Nat Rev Mol Cell Biol. 2024. PMID: 38684868 Review.
Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML.
Bourgeois W, Cutler JA, Aubrey BJ, Wenge DV, Perner F, Martucci C, Henrich JA, Klega K, Nowak RP, Donovan KA, Boileau M, Wen Y, Hatton C, Apazidis AA, Olsen SN, Kirmani N, Pikman Y, Pollard JA, Perry JA, Sperling AS, Ebert BL, McGeehan GM, Crompton BD, Fischer ES, Armstrong SA. Bourgeois W, et al. Among authors: nowak rp. Blood. 2024 Apr 11;143(15):1513-1527. doi: 10.1182/blood.2023021105. Blood. 2024. PMID: 38096371
The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein.
Zou C, Yoon H, Park PMC, Patten JJ, Pellman J, Carreiro J, Tsai JM, Li YD, Roy Burman SS, Donovan KA, Gasser J, Sperling AS, Nowak RP, Fischer ES, Davey RA, Ebert BL, Słabicki M. Zou C, et al. Among authors: nowak rp. iScience. 2023 May 19;26(5):106601. doi: 10.1016/j.isci.2023.106601. Epub 2023 Apr 8. iScience. 2023. PMID: 37095859 Free PMC article.
67 results