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The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.
Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A, Stehlik C. Khare S, et al. Among authors: ratsimandresy ra. Nat Immunol. 2014 Apr;15(4):343-53. doi: 10.1038/ni.2829. Epub 2014 Feb 16. Nat Immunol. 2014. PMID: 24531343 Free PMC article.
POP1 inhibits MSU-induced inflammasome activation and ameliorates gout.
de Almeida L, Devi S, Indramohan M, Huang QQ, Ratsimandresy RA, Pope RM, Dorfleutner A, Stehlik C. de Almeida L, et al. Among authors: ratsimandresy ra. Front Immunol. 2022 Sep 26;13:912069. doi: 10.3389/fimmu.2022.912069. eCollection 2022. Front Immunol. 2022. PMID: 36225929 Free PMC article.
NLRP3 licenses NLRP11 for inflammasome activation in human macrophages.
Gangopadhyay A, Devi S, Tenguria S, Carriere J, Nguyen H, Jäger E, Khatri H, Chu LH, Ratsimandresy RA, Dorfleutner A, Stehlik C. Gangopadhyay A, et al. Among authors: ratsimandresy ra. Nat Immunol. 2022 Jun;23(6):892-903. doi: 10.1038/s41590-022-01220-3. Epub 2022 May 27. Nat Immunol. 2022. PMID: 35624206 Free PMC article.
Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation.
Dagvadorj J, Mikulska-Ruminska K, Tumurkhuu G, Ratsimandresy RA, Carriere J, Andres AM, Marek-Iannucci S, Song Y, Chen S, Lane M, Dorfleutner A, Gottlieb RA, Stehlik C, Cassel S, Sutterwala FS, Bahar I, Crother TR, Arditi M. Dagvadorj J, et al. Among authors: ratsimandresy ra. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2015632118. doi: 10.1073/pnas.2015632118. Proc Natl Acad Sci U S A. 2021. PMID: 33361152 Free PMC article.
Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma.
Headland SE, Dengler HS, Xu D, Teng G, Everett C, Ratsimandresy RA, Yan D, Kang J, Ganeshan K, Nazarova EV, Gierke S, Wedeles CJ, Guidi R, DePianto DJ, Morshead KB, Huynh A, Mills J, Flanagan S, Hambro S, Nunez V, Klementowicz JE, Shi Y, Wang J, Bevers J 3rd, Ramirez-Carrozzi V, Pappu R, Abbas A, Vander Heiden J, Choy DF, Yadav R, Modrusan Z, Panettieri RA Jr, Koziol-White C, Jester WF Jr, Jenkins BJ, Cao Y, Clarke C, Austin C, Lafkas D, Xu M, Wolters PJ, Arron JR, West NR, Wilson MS. Headland SE, et al. Among authors: ratsimandresy ra. Sci Transl Med. 2022 Jan 12;14(627):eabf8188. doi: 10.1126/scitranslmed.abf8188. Epub 2022 Jan 12. Sci Transl Med. 2022. PMID: 35020406
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