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Page 1
Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer.
Zhang Y, Seigal BA, Terrett NK, Talbott RL, Fargnoli J, Naglich JG, Chaudhry C, Posy SL, Vuppugalla R, Cornelius G, Lei M, Wang C, Zhang Y, Schmidt RJ, Wei DD, Miller MM, Allen MP, Li L, Carter PH, Vite GD, Borzilleri RM. Zhang Y, et al. Among authors: terrett nk. ACS Med Chem Lett. 2015 May 27;6(7):770-5. doi: 10.1021/acsmedchemlett.5b00091. eCollection 2015 Jul 9. ACS Med Chem Lett. 2015. PMID: 26191364 Free PMC article.
The discovery of macrocyclic XIAP antagonists from a DNA-programmed chemistry library, and their optimization to give lead compounds with in vivo antitumor activity.
Seigal BA, Connors WH, Fraley A, Borzilleri RM, Carter PH, Emanuel SL, Fargnoli J, Kim K, Lei M, Naglich JG, Pokross ME, Posy SL, Shen H, Surti N, Talbott R, Zhang Y, Terrett NK. Seigal BA, et al. Among authors: terrett nk. J Med Chem. 2015 Mar 26;58(6):2855-61. doi: 10.1021/jm501892g. Epub 2015 Mar 12. J Med Chem. 2015. PMID: 25695766 Free article.
DNA-encoded chemical libraries of macrocycles.
Connors WH, Hale SP, Terrett NK. Connors WH, et al. Among authors: terrett nk. Curr Opin Chem Biol. 2015 Jun;26:42-7. doi: 10.1016/j.cbpa.2015.02.004. Epub 2015 Feb 21. Curr Opin Chem Biol. 2015. PMID: 25710630 Review. No abstract available.
Combinatorial chemistry.
Terrett N. Terrett N. Drug Discov Today. 1999 May;4(5):239-240. doi: 10.1016/s1359-6446(99)01351-3. Drug Discov Today. 1999. PMID: 10322292 No abstract available.
36 results