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Page 1
Elucidating Compound Mechanism of Action by Network Perturbation Analysis.
Woo JH, Shimoni Y, Yang WS, Subramaniam P, Iyer A, Nicoletti P, Rodríguez Martínez M, López G, Mattioli M, Realubit R, Karan C, Stockwell BR, Bansal M, Califano A. Woo JH, et al. Among authors: karan c. Cell. 2015 Jul 16;162(2):441-451. doi: 10.1016/j.cell.2015.05.056. Cell. 2015. PMID: 26186195 Free PMC article.
Convection-enhanced delivery of etoposide is effective against murine proneural glioblastoma.
Sonabend AM, Carminucci AS, Amendolara B, Bansal M, Leung R, Lei L, Realubit R, Li H, Karan C, Yun J, Showers C, Rothcock R, O J, Califano A, Canoll P, Bruce JN. Sonabend AM, et al. Among authors: karan c. Neuro Oncol. 2014 Sep;16(9):1210-9. doi: 10.1093/neuonc/nou026. Epub 2014 Mar 16. Neuro Oncol. 2014. PMID: 24637229 Free PMC article.
A community computational challenge to predict the activity of pairs of compounds.
Bansal M, Yang J, Karan C, Menden MP, Costello JC, Tang H, Xiao G, Li Y, Allen J, Zhong R, Chen B, Kim M, Wang T, Heiser LM, Realubit R, Mattioli M, Alvarez MJ, Shen Y; NCI-DREAM Community; Gallahan D, Singer D, Saez-Rodriguez J, Xie Y, Stolovitzky G, Califano A; NCI-DREAM Community. Bansal M, et al. Among authors: karan c. Nat Biotechnol. 2014 Dec;32(12):1213-22. doi: 10.1038/nbt.3052. Epub 2014 Nov 17. Nat Biotechnol. 2014. PMID: 25419740 Free PMC article.
Preclinical pharmacologic evaluation of pralatrexate and romidepsin confirms potent synergy of the combination in a murine model of human T-cell lymphoma.
Jain S, Jirau-Serrano X, Zullo KM, Scotto L, Palermo CF, Sastra SA, Olive KP, Cremers S, Thomas T, Wei Y, Zhang Y, Bhagat G, Amengual JE, Deng C, Karan C, Realubit R, Bates SE, O'Connor OA. Jain S, et al. Among authors: karan c. Clin Cancer Res. 2015 May 1;21(9):2096-106. doi: 10.1158/1078-0432.CCR-14-2249. Epub 2015 Feb 12. Clin Cancer Res. 2015. PMID: 25677697
TSH Receptor Signaling Abrogation by a Novel Small Molecule.
Latif R, Realubit RB, Karan C, Mezei M, Davies TF. Latif R, et al. Among authors: karan c. Front Endocrinol (Lausanne). 2016 Sep 27;7:130. doi: 10.3389/fendo.2016.00130. eCollection 2016. Front Endocrinol (Lausanne). 2016. PMID: 27729899 Free PMC article.
Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies.
Deng C, Lipstein MR, Scotto L, Jirau Serrano XO, Mangone MA, Li S, Vendome J, Hao Y, Xu X, Deng SX, Realubit RB, Tatonetti NP, Karan C, Lentzsch S, Fruman DA, Honig B, Landry DW, O'Connor OA. Deng C, et al. Among authors: karan c. Blood. 2017 Jan 5;129(1):88-99. doi: 10.1182/blood-2016-08-731240. Epub 2016 Oct 26. Blood. 2017. PMID: 27784673 Free PMC article.
PI3Kγ/δ and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature.
Efimenko E, Davé UP, Lebedeva IV, Shen Y, Sanchez-Quintero MJ, Diolaiti D, Kung A, Lannutti BJ, Chen J, Realubit R, Niatsetskaya Z, Ten V, Karan C, Chen X, Califano A, Diacovo TG. Efimenko E, et al. Among authors: karan c. Mol Cancer Ther. 2017 Oct;16(10):2069-2082. doi: 10.1158/1535-7163.MCT-17-0141. Epub 2017 Jul 17. Mol Cancer Ther. 2017. PMID: 28716817 Free PMC article.
62 results