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The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming.
Phan L, Chou PC, Velazquez-Torres G, Samudio I, Parreno K, Huang Y, Tseng C, Vu T, Gully C, Su CH, Wang E, Chen J, Choi HH, Fuentes-Mattei E, Shin JH, Shiang C, Grabiner B, Blonska M, Skerl S, Shao Y, Cody D, Delacerda J, Kingsley C, Webb D, Carlock C, Zhou Z, Hsieh YC, Lee J, Elliott A, Ramirez M, Bankson J, Hazle J, Wang Y, Li L, Weng S, Rizk N, Wen YY, Lin X, Wang H, Wang H, Zhang A, Xia X, Wu Y, Habra M, Yang W, Pusztai L, Yeung SC, Lee MH. Phan L, et al. Among authors: hsieh yc. Nat Commun. 2015 Jul 16;6:7530. doi: 10.1038/ncomms8530. Nat Commun. 2015. PMID: 26179207 Free PMC article.
CSN6 drives carcinogenesis by positively regulating Myc stability.
Chen J, Shin JH, Zhao R, Phan L, Wang H, Xue Y, Post SM, Ho Choi H, Chen JS, Wang E, Zhou Z, Tseng C, Gully C, Velazquez-Torres G, Fuentes-Mattei E, Yeung G, Qiao Y, Chou PC, Su CH, Hsieh YC, Hsu SL, Ohshiro K, Shaikenov T, Wang H, Yeung SC, Lee MH. Chen J, et al. Among authors: hsieh yc. Nat Commun. 2014 Nov 14;5:5384. doi: 10.1038/ncomms6384. Nat Commun. 2014. PMID: 25395170 Free PMC article.
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ.
Kiourtis C, Terradas-Terradas M, Gee LM, May S, Georgakopoulou A, Collins AL, O'Sullivan ED, Baird DP, Hassan M, Shaw R, Tan EH, Müller M, Engelmann C, Andreola F, Hsieh YC, Reed LH, Borthwick LA, Nixon C, Clark W, Hanson PS, Sumpton D, Mackay G, Suzuki T, Najumudeen AK, Inman GJ, Campbell A, Barry ST, Quaglia A, Morris CM, LeBeau FEN, Sansom OJ, Kirschner K, Jalan R, Oakley F, Bird TG. Kiourtis C, et al. Among authors: hsieh yc. Nat Cell Biol. 2024 Nov 13. doi: 10.1038/s41556-024-01543-3. Online ahead of print. Nat Cell Biol. 2024. PMID: 39537753
908 results