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Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis.
Bunnage ME, Blagg J, Steele J, Owen DR, Allerton C, McElroy AB, Miller D, Ringer T, Butcher K, Beaumont K, Evans K, Gray AJ, Holland SJ, Feeder N, Moore RS, Brown DG. Bunnage ME, et al. Among authors: allerton c. J Med Chem. 2007 Nov 29;50(24):6095-103. doi: 10.1021/jm0702433. Epub 2007 Nov 9. J Med Chem. 2007. PMID: 17990866
Design and synthesis of pyridazinone-based 5-HT(2C) agonists.
Allerton CM, Andrews MD, Blagg J, Ellis D, Evrard E, Green MP, Liu KK, McMurray G, Ralph M, Sanderson V, Ward R, Watson L. Allerton CM, et al. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5791-5. doi: 10.1016/j.bmcl.2009.07.136. Epub 2009 Aug 6. Bioorg Med Chem Lett. 2009. PMID: 19716297
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Owen DR, Allerton CMN, Anderson AS, Aschenbrenner L, Avery M, Berritt S, Boras B, Cardin RD, Carlo A, Coffman KJ, Dantonio A, Di L, Eng H, Ferre R, Gajiwala KS, Gibson SA, Greasley SE, Hurst BL, Kadar EP, Kalgutkar AS, Lee JC, Lee J, Liu W, Mason SW, Noell S, Novak JJ, Obach RS, Ogilvie K, Patel NC, Pettersson M, Rai DK, Reese MR, Sammons MF, Sathish JG, Singh RSP, Steppan CM, Stewart AE, Tuttle JB, Updyke L, Verhoest PR, Wei L, Yang Q, Zhu Y. Owen DR, et al. Among authors: allerton cmn. Science. 2021 Dec 24;374(6575):1586-1593. doi: 10.1126/science.abl4784. Epub 2021 Nov 2. Science. 2021. PMID: 34726479 Free article.
Reviving an R&D pipeline: a step change in the Phase II success rate.
Wu SS, Fernando K, Allerton C, Jansen KU, Vincent MS, Dolsten M. Wu SS, et al. Among authors: allerton c. Drug Discov Today. 2021 Feb;26(2):308-314. doi: 10.1016/j.drudis.2020.10.019. Epub 2020 Oct 28. Drug Discov Today. 2021. PMID: 33129994 Free article. Review.
18 results