Lam LT - Search Results

1

Genomic analysis and selective small molecule inhibition identifies BCL-X(L) as a critical survival factor in a subset of colorectal cancer.

Zhang H, Xue J, Hessler P, Tahir SK, Chen J, Jin S, Souers AJ, Leverson JD, Lam LT. Zhang H, et al. Among authors: lam lt. Mol Cancer. 2015 Jul 2;14:126. doi: 10.1186/s12943-015-0397-y. Mol Cancer. 2015. PMID: 26134786 Free PMC article.

2

A microRNA screen to identify modulators of sensitivity to BCL2 inhibitor ABT-263 (navitoclax).

Lam LT, Lu X, Zhang H, Lesniewski R, Rosenberg S, Semizarov D. Lam LT, et al. Mol Cancer Ther. 2010 Nov;9(11):2943-50. doi: 10.1158/1535-7163.MCT-10-0427. Epub 2010 Sep 9. Mol Cancer Ther. 2010. PMID: 20829195

3

Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines.

Zhang H, Guttikonda S, Roberts L, Uziel T, Semizarov D, Elmore SW, Leverson JD, Lam LT. Zhang H, et al. Among authors: lam lt. Oncogene. 2011 Apr 21;30(16):1963-8. doi: 10.1038/onc.2010.559. Epub 2010 Dec 6. Oncogene. 2011. PMID: 21132008

4

Biomarkers of therapeutic response to BCL2 antagonists in cancer.

Lam LT, Zhang H, Chyla B. Lam LT, et al. Mol Diagn Ther. 2012 Dec;16(6):347-56. doi: 10.1007/s40291-012-0003-6. Mol Diagn Ther. 2012. PMID: 23023732 Review.

5

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.

Souers AJ, Leverson JD, Boghaert ER, Ackler SL, Catron ND, Chen J, Dayton BD, Ding H, Enschede SH, Fairbrother WJ, Huang DC, Hymowitz SG, Jin S, Khaw SL, Kovar PJ, Lam LT, Lee J, Maecker HL, Marsh KC, Mason KD, Mitten MJ, Nimmer PM, Oleksijew A, Park CH, Park CM, Phillips DC, Roberts AW, Sampath D, Seymour JF, Smith ML, Sullivan GM, Tahir SK, Tse C, Wendt MD, Xiao Y, Xue JC, Zhang H, Humerickhouse RA, Rosenberg SH, Elmore SW. Souers AJ, et al. Among authors: lam lt. Nat Med. 2013 Feb;19(2):202-8. doi: 10.1038/nm.3048. Epub 2013 Jan 6. Nat Med. 2013. PMID: 23291630

6

Multiplex analysis of anti-apoptotic BCL2 family and caspase 3 activation by microbead arrays.

Lam LT, Roberts-Rapp L. Lam LT, et al. Assay Drug Dev Technol. 2014 Apr;12(3):190-6. doi: 10.1089/adt.2013.557. Assay Drug Dev Technol. 2014. PMID: 24735445

7

Antihelminthic benzimidazoles potentiate navitoclax (ABT-263) activity by inducing Noxa-dependent apoptosis in non-small cell lung cancer (NSCLC) cell lines.

Lam LT, Zhang H, Xue J, Leverson JD, Bhathena A. Lam LT, et al. Cancer Cell Int. 2015 Feb 4;15(1):5. doi: 10.1186/s12935-014-0151-3. eCollection 2015. Cancer Cell Int. 2015. PMID: 25685063 Free PMC article.

8

Loss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199).

Phillips DC, Xiao Y, Lam LT, Litvinovich E, Roberts-Rapp L, Souers AJ, Leverson JD. Phillips DC, et al. Among authors: lam lt. Blood Cancer J. 2015 Nov 13;5(11):e368. doi: 10.1038/bcj.2015.88. Blood Cancer J. 2015. PMID: 26565405 Free PMC article.

9

Loss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199).

Phillips DC, Xiao Y, Lam LT, Litvinovich E, Roberts-Rapp L, Souers AJ, Leverson JD. Phillips DC, et al. Among authors: lam lt. Blood Cancer J. 2016 Mar 11;6(3):e403. doi: 10.1038/bcj.2016.12. Blood Cancer J. 2016. PMID: 26967820 Free PMC article. No abstract available.

10

Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies.

Bui MH, Lin X, Albert DH, Li L, Lam LT, Faivre EJ, Warder SE, Huang X, Wilcox D, Donawho CK, Sheppard GS, Wang L, Fidanze S, Pratt JK, Liu D, Hasvold L, Uziel T, Lu X, Kohlhapp F, Fang G, Elmore SW, Rosenberg SH, McDaniel KF, Kati WM, Shen Y. Bui MH, et al. Among authors: lam lt. Cancer Res. 2017 Jun 1;77(11):2976-2989. doi: 10.1158/0008-5472.CAN-16-1793. Epub 2017 Apr 17. Cancer Res. 2017. PMID: 28416490

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