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Page 1
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.
Draisma HHM, Pool R, Kobl M, Jansen R, Petersen AK, Vaarhorst AAM, Yet I, Haller T, Demirkan A, Esko T, Zhu G, Böhringer S, Beekman M, van Klinken JB, Römisch-Margl W, Prehn C, Adamski J, de Craen AJM, van Leeuwen EM, Amin N, Dharuri H, Westra HJ, Franke L, de Geus EJC, Hottenga JJ, Willemsen G, Henders AK, Montgomery GW, Nyholt DR, Whitfield JB, Penninx BW, Spector TD, Metspalu A, Slagboom PE, van Dijk KW, 't Hoen PAC, Strauch K, Martin NG, van Ommen GB, Illig T, Bell JT, Mangino M, Suhre K, McCarthy MI, Gieger C, Isaacs A, van Duijn CM, Boomsma DI. Draisma HHM, et al. Among authors: vaarhorst aam. Nat Commun. 2015 Jun 12;6:7208. doi: 10.1038/ncomms8208. Nat Commun. 2015. PMID: 26068415 Free PMC article.
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.
Kettunen J, Demirkan A, Würtz P, Draisma HH, Haller T, Rawal R, Vaarhorst A, Kangas AJ, Lyytikäinen LP, Pirinen M, Pool R, Sarin AP, Soininen P, Tukiainen T, Wang Q, Tiainen M, Tynkkynen T, Amin N, Zeller T, Beekman M, Deelen J, van Dijk KW, Esko T, Hottenga JJ, van Leeuwen EM, Lehtimäki T, Mihailov E, Rose RJ, de Craen AJ, Gieger C, Kähönen M, Perola M, Blankenberg S, Savolainen MJ, Verhoeven A, Viikari J, Willemsen G, Boomsma DI, van Duijn CM, Eriksson J, Jula A, Järvelin MR, Kaprio J, Metspalu A, Raitakari O, Salomaa V, Slagboom PE, Waldenberger M, Ripatti S, Ala-Korpela M. Kettunen J, et al. Nat Commun. 2016 Mar 23;7:11122. doi: 10.1038/ncomms11122. Nat Commun. 2016. PMID: 27005778 Free PMC article.
Familial resemblance for serum metabolite concentrations.
Draisma HH, Beekman M, Pool R, van Ommen GJ, Adamski J, Prehn C, Vaarhorst AA, de Craen AJ, Willemsen G, Slagboom PE, Boomsma DI. Draisma HH, et al. Twin Res Hum Genet. 2013 Oct;16(5):948-61. doi: 10.1017/thg.2013.59. Epub 2013 Aug 28. Twin Res Hum Genet. 2013. PMID: 23985338
Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium.
van der Spek A, Broer L, Draisma HHM, Pool R, Albrecht E, Beekman M, Mangino M, Raag M, Nyholt DR, Dharuri HK, Codd V, Amin N, de Geus EJC, Deelen J, Demirkan A, Yet I, Fischer K, Haller T, Henders AK, Isaacs A, Medland SE, Montgomery GW, Mooijaart SP, Strauch K, Suchiman HED, Vaarhorst AAM, van Heemst D, Wang-Sattler R, Whitfield JB, Willemsen G, Wright MJ, Martin NG, Samani NJ, Metspalu A, Eline Slagboom P, Spector TD, Boomsma DI, van Duijn CM, Gieger C. van der Spek A, et al. Among authors: vaarhorst aam. Sci Rep. 2019 Aug 12;9(1):11623. doi: 10.1038/s41598-019-47282-6. Sci Rep. 2019. PMID: 31406173 Free PMC article.
A metabolomic profile is associated with the risk of incident coronary heart disease.
Vaarhorst AA, Verhoeven A, Weller CM, Böhringer S, Göraler S, Meissner A, Deelder AM, Henneman P, Gorgels AP, van den Brandt PA, Schouten LJ, van Greevenbroek MM, Merry AH, Verschuren WM, van den Maagdenberg AM, van Dijk KW, Isaacs A, Boomsma D, Oostra BA, van Duijn CM, Jukema JW, Boer JM, Feskens E, Heijmans BT, Slagboom PE. Vaarhorst AA, et al. Am Heart J. 2014 Jul;168(1):45-52.e7. doi: 10.1016/j.ahj.2014.01.019. Epub 2014 Apr 4. Am Heart J. 2014. PMID: 24952859 Free article.
Lipid metabolism in long-lived families: the Leiden Longevity Study.
Vaarhorst AA, Beekman M, Suchiman EH, van Heemst D, Houwing-Duistermaat JJ, Westendorp RG, Slagboom PE, Heijmans BT; Leiden Longevity Study (LLS) Group. Vaarhorst AA, et al. Age (Dordr). 2011 Jun;33(2):219-27. doi: 10.1007/s11357-010-9172-6. Epub 2010 Sep 3. Age (Dordr). 2011. PMID: 20811950 Free PMC article.
Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study.
Vaarhorst AA, Lu Y, Heijmans BT, Dollé ME, Böhringer S, Putter H, Imholz S, Merry AH, van Greevenbroek MM, Jukema JW, Gorgels AP, van den Brandt PA, Müller M, Schouten LJ, Feskens EJ, Boer JM, Slagboom PE. Vaarhorst AA, et al. Circ Cardiovasc Genet. 2012 Apr 1;5(2):202-9. doi: 10.1161/CIRCGENETICS.111.960708. Epub 2012 Feb 28. Circ Cardiovasc Genet. 2012. PMID: 22373668
Genomics of human longevity.
Slagboom PE, Beekman M, Passtoors WM, Deelen J, Vaarhorst AA, Boer JM, van den Akker EB, van Heemst D, de Craen AJ, Maier AB, Rozing M, Mooijaart SP, Heijmans BT, Westendorp RG. Slagboom PE, et al. Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12;366(1561):35-42. doi: 10.1098/rstb.2010.0284. Philos Trans R Soc Lond B Biol Sci. 2011. PMID: 21115528 Free PMC article. Review.
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