Young M - Search Results

1

Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling.

Chou DH, Vetere A, Choudhary A, Scully SS, Schenone M, Tang A, Gomez R, Burns SM, Lundh M, Vital T, Comer E, Faloon PW, Dančík V, Ciarlo C, Paulk J, Dai M, Reddy C, Sun H, Young M, Donato N, Jaffe J, Clemons PA, Palmer M, Carr SA, Schreiber SL, Wagner BK. Chou DH, et al. Among authors: young m. J Am Chem Soc. 2015 Jun 24;137(24):7929-34. doi: 10.1021/jacs.5b04284. Epub 2015 Jun 15. J Am Chem Soc. 2015. PMID: 26042473 Free PMC article.

2

Emerging potential of therapeutic targeting of ubiquitin-specific proteases in the treatment of cancer.

Pal A, Young MA, Donato NJ. Pal A, et al. Cancer Res. 2014 Sep 15;74(18):4955-66. doi: 10.1158/0008-5472.CAN-14-1211. Epub 2014 Aug 29. Cancer Res. 2014. PMID: 25172841 Review.

3

Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies.

Peterson LF, Sun H, Liu Y, Potu H, Kandarpa M, Ermann M, Courtney SM, Young M, Showalter HD, Sun D, Jakubowiak A, Malek SN, Talpaz M, Donato NJ. Peterson LF, et al. Among authors: young m. Blood. 2015 Jun 4;125(23):3588-97. doi: 10.1182/blood-2014-10-605584. Epub 2015 Mar 26. Blood. 2015. PMID: 25814533 Free article.

4

Degrasyn-like symmetrical compounds: possible therapeutic agents for multiple myeloma (MM-I).

Peng Z, Maxwell DS, Sun D, Bhanu Prasad BA, Schuber PT Jr, Pal A, Ying Y, Han D, Gao L, Wang S, Levitzki A, Kapuria V, Talpaz M, Young M, Showalter HD, Donato NJ, Bornmann WG. Peng Z, et al. Among authors: young m. Bioorg Med Chem. 2014 Feb 15;22(4):1450-8. doi: 10.1016/j.bmc.2013.12.048. Epub 2014 Jan 3. Bioorg Med Chem. 2014. PMID: 24457091 Free PMC article.

5

Price to be paid for two-metal catalysis: magnesium ions that accelerate chemistry unavoidably limit product release from a protein kinase.

Jacobsen DM, Bao ZQ, O'Brien P, Brooks CL 3rd, Young MA. Jacobsen DM, et al. Among authors: young ma. J Am Chem Soc. 2012 Sep 19;134(37):15357-70. doi: 10.1021/ja304419t. Epub 2012 Sep 7. J Am Chem Soc. 2012. PMID: 22891849 Free PMC article.

6

Regulation of luteinizing hormone receptor mRNA expression by mevalonate kinase--role of the catalytic center in mRNA recognition.

Nair AK, Young MA, Menon KM. Nair AK, et al. Among authors: young ma. FEBS J. 2008 Jul;275(13):3397-407. doi: 10.1111/j.1742-4658.2008.06490.x. Epub 2008 May 20. FEBS J. 2008. PMID: 18494797 Free article.

7

Structure of a thyroid hormone receptor DNA-binding domain homodimer bound to an inverted palindrome DNA response element.

Chen Y, Young MA. Chen Y, et al. Mol Endocrinol. 2010 Aug;24(8):1650-64. doi: 10.1210/me.2010-0129. Epub 2010 Jul 7. Mol Endocrinol. 2010. PMID: 20610536 Free PMC article.

8

Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis.

Bao ZQ, Jacobsen DM, Young MA. Bao ZQ, et al. Among authors: young ma. Structure. 2011 May 11;19(5):675-90. doi: 10.1016/j.str.2011.02.016. Structure. 2011. PMID: 21565702 Free PMC article.

9

Addressing the Reproducibility Crisis in Science: It's About Time.

Young M, Mann DL. Young M, et al. JACC Basic Transl Sci. 2024 Oct 28;9(10):1266-1267. doi: 10.1016/j.jacbts.2024.09.005. eCollection 2024 Oct. JACC Basic Transl Sci. 2024. PMID: 39534635 Free PMC article. No abstract available.

10

An early HMGB1 rise 12 hours before creatinine predicts acute kidney injury and multiple organ failure in a smoke inhalation and burn swine model.

Yang Z, Cancio TS, Willis RP, Young MD, Kneifel DM, Salinas J, Meyer AD. Yang Z, et al. Among authors: young md. Front Immunol. 2024 Oct 29;15:1447597. doi: 10.3389/fimmu.2024.1447597. eCollection 2024. Front Immunol. 2024. PMID: 39534595 Free PMC article.

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