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Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling.
Chou DH, Vetere A, Choudhary A, Scully SS, Schenone M, Tang A, Gomez R, Burns SM, Lundh M, Vital T, Comer E, Faloon PW, Dančík V, Ciarlo C, Paulk J, Dai M, Reddy C, Sun H, Young M, Donato N, Jaffe J, Clemons PA, Palmer M, Carr SA, Schreiber SL, Wagner BK. Chou DH, et al. J Am Chem Soc. 2015 Jun 24;137(24):7929-34. doi: 10.1021/jacs.5b04284. Epub 2015 Jun 15. J Am Chem Soc. 2015. PMID: 26042473 Free PMC article.
The immunoproteasome is induced by cytokines and regulates apoptosis in human islets.
Lundh M, Bugliani M, Dahlby T, Chou DH, Wagner B, Ghiasi SM, De Tata V, Chen Z, Lund MN, Davies MJ, Marchetti P, Mandrup-Poulsen T. Lundh M, et al. Among authors: chou dh. J Endocrinol. 2017 Jun;233(3):369-379. doi: 10.1530/JOE-17-0110. Epub 2017 Apr 24. J Endocrinol. 2017. PMID: 28438776 Free PMC article.
Novel four-disulfide insulin analog with high aggregation stability and potency.
Xiong X, Blakely A, Karra P, VandenBerg MA, Ghabash G, Whitby F, Zhang YW, Webber MJ, Holland WL, Hill CP, Chou DH. Xiong X, et al. Among authors: chou dh. Chem Sci. 2019 Nov 5;11(1):195-200. doi: 10.1039/c9sc04555d. eCollection 2020 Jan 7. Chem Sci. 2019. PMID: 32110371 Free PMC article.
Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain.
Zheng N, Christensen SB, Dowell C, Purushottam L, Skalicky JJ, McIntosh JM, Chou DH. Zheng N, et al. Among authors: chou dh. J Med Chem. 2021 Jul 8;64(13):9513-9524. doi: 10.1021/acs.jmedchem.1c00802. Epub 2021 Jun 23. J Med Chem. 2021. PMID: 34161094 Free PMC article.
Glucose-Responsive Insulin Through Bioconjugation Approaches.
Disotuar MM, Chen D, Lin NP, Chou DH. Disotuar MM, et al. Among authors: chou dh. J Diabetes Sci Technol. 2020 Mar;14(2):198-203. doi: 10.1177/1932296819854105. Epub 2019 Jun 19. J Diabetes Sci Technol. 2020. PMID: 31216874 Free PMC article. Review.
40 results