Prashad M - Search Results

1

(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.

Choi HS, Rucker PV, Wang Z, Fan Y, Albaugh P, Chopiuk G, Gessier F, Sun F, Adrian F, Liu G, Hood T, Li N, Jia Y, Che J, McCormack S, Li A, Li J, Steffy A, Culazzo A, Tompkins C, Phung V, Kreusch A, Lu M, Hu B, Chaudhary A, Prashad M, Tuntland T, Liu B, Harris J, Seidel HM, Loren J, Molteni V. Choi HS, et al. Among authors: prashad m. ACS Med Chem Lett. 2015 Mar 16;6(5):562-7. doi: 10.1021/acsmedchemlett.5b00050. eCollection 2015 May 14. ACS Med Chem Lett. 2015. PMID: 26005534 Free PMC article.

2

Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.

Chianelli D, Rucker PV, Roland J, Tully DC, Nelson J, Liu X, Bursulaya B, Hernandez ED, Wu J, Prashad M, Schlama T, Liu Y, Chu A, Schmeits J, Huang DJ, Hill R, Bao D, Zoll J, Kim Y, Groessl T, McNamara P, Liu B, Richmond W, Sancho-Martinez I, Phimister A, Seidel HM, Badman MK, Joseph SB, Laffitte B, Molteni V. Chianelli D, et al. Among authors: prashad m. J Med Chem. 2020 Apr 23;63(8):3868-3880. doi: 10.1021/acs.jmedchem.9b01621. Epub 2020 Feb 5. J Med Chem. 2020. PMID: 31940200

3

Asymmetric synthesis of homoallylic amines bearing adjacent stereogenic centers by addition of substituted allylic zinc reagents to N-tert-butanesulfinylimines.

Reddy LR, Hu B, Prashad M, Prasad K. Reddy LR, et al. Among authors: prashad m. Org Lett. 2008 Jul 17;10(14):3109-12. doi: 10.1021/ol800998u. Epub 2008 Jun 11. Org Lett. 2008. PMID: 18543938

4

An unexpected reaction of arenesulfonyl cyanides with allylic alcohols: preparation of trisubstituted allyl sulfones.

Reddy LR, Hu B, Prashad M, Prasad K. Reddy LR, et al. Among authors: prashad m. Angew Chem Int Ed Engl. 2009;48(1):172-4. doi: 10.1002/anie.200803836. Angew Chem Int Ed Engl. 2009. PMID: 19040260 No abstract available.

5

An efficient and practical N-methylation of amino acid derivatives.

Prashad M, Har D, Hu B, Kim HY, Repic O, Blacklock TJ. Prashad M, et al. Org Lett. 2003 Jan 23;5(2):125-8. doi: 10.1021/ol0268440. Org Lett. 2003. PMID: 12529121

6

Discovery of novel non-peptidic beta-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists.

Troxler T, Hurth K, Mattes H, Prashad M, Schoeffter P, Langenegger D, Enz A, Hoyer D. Troxler T, et al. Among authors: prashad m. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1305-9. doi: 10.1016/j.bmcl.2009.01.072. Epub 2009 Jan 27. Bioorg Med Chem Lett. 2009. PMID: 19208473

7

beta-hydrogen-containing sodium alkoxides as suitable bases in palladium-catalyzed aminations of aryl halides.

Prashad M, Hu B, Lu Y, Draper R, Har D, Repic O, Blacklock TJ. Prashad M, et al. J Org Chem. 2000 Apr 21;65(8):2612-4. doi: 10.1021/jo991949a. J Org Chem. 2000. PMID: 10789487 No abstract available.

8

Enantioselective hydrogenation of alpha-aminomethylacrylates containing a free NH group for the synthesis of beta-amino acid derivatives.

Qiu L, Prashad M, Hu B, Prasad K, Repic O, Blacklock TJ, Kwong FY, Kok SH, Lee HW, Chan AS. Qiu L, et al. Among authors: prashad m. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16787-92. doi: 10.1073/pnas.0704461104. Epub 2007 Oct 17. Proc Natl Acad Sci U S A. 2007. PMID: 17942689 Free PMC article.

9

Asymmetric synthesis of 2-substituted pyrrolidines by addition of Grignard reagents to gamma-chlorinated N-tert-butanesulfinyl imine.

Reddy LR, Prashad M. Reddy LR, et al. Among authors: prashad m. Chem Commun (Camb). 2010 Jan 14;46(2):222-4. doi: 10.1039/b917435d. Epub 2009 Nov 24. Chem Commun (Camb). 2010. PMID: 20024332

10

An efficient and large-scale enantioselective synthesis of PNP405: a purine nucleoside phosphorylase inhibitor.

Prashad M, Har D, Chen L, Kim HY, Repic O, Blacklock TJ. Prashad M, et al. J Org Chem. 2002 Sep 20;67(19):6612-7. doi: 10.1021/jo020256i. J Org Chem. 2002. PMID: 12227788

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