Wardell SE - Search Results

1

Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer.

Wardell SE, Ellis MJ, Alley HM, Eisele K, VanArsdale T, Dann SG, Arndt KT, Primeau T, Griffin E, Shao J, Crowder R, Lai JP, Norris JD, McDonnell DP, Li S. Wardell SE, et al. Clin Cancer Res. 2015 Nov 15;21(22):5121-5130. doi: 10.1158/1078-0432.CCR-15-0360. Epub 2015 May 19. Clin Cancer Res. 2015. PMID: 25991817 Free PMC article.

2

Glucose metabolism as a target of histone deacetylase inhibitors.

Wardell SE, Ilkayeva OR, Wieman HL, Frigo DE, Rathmell JC, Newgard CB, McDonnell DP. Wardell SE, et al. Mol Endocrinol. 2009 Mar;23(3):388-401. doi: 10.1210/me.2008-0179. Epub 2008 Dec 23. Mol Endocrinol. 2009. PMID: 19106193 Free PMC article.

3

The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer.

McDonnell DP, Wardell SE. McDonnell DP, et al. Among authors: wardell se. Curr Opin Pharmacol. 2010 Dec;10(6):620-8. doi: 10.1016/j.coph.2010.09.007. Curr Opin Pharmacol. 2010. PMID: 20926342 Free PMC article. Review.

4

The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy.

Wardell SE, Marks JR, McDonnell DP. Wardell SE, et al. Biochem Pharmacol. 2011 Jul 15;82(2):122-30. doi: 10.1016/j.bcp.2011.03.031. Epub 2011 Apr 9. Biochem Pharmacol. 2011. PMID: 21501600 Free PMC article.

5

Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes.

Wardell SE, Kazmin D, McDonnell DP. Wardell SE, et al. Mol Endocrinol. 2012 Jul;26(7):1235-48. doi: 10.1210/me.2012-1031. Epub 2012 May 8. Mol Endocrinol. 2012. PMID: 22570330 Free PMC article.

6

The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis.

Nelson ER, Wardell SE, McDonnell DP. Nelson ER, et al. Among authors: wardell se. Bone. 2013 Mar;53(1):42-50. doi: 10.1016/j.bone.2012.11.011. Epub 2012 Nov 17. Bone. 2013. PMID: 23168292 Free PMC article. Review.

7

Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease.

Wardell SE, Nelson ER, Chao CA, McDonnell DP. Wardell SE, et al. Clin Cancer Res. 2013 May 1;19(9):2420-31. doi: 10.1158/1078-0432.CCR-12-3771. Epub 2013 Mar 27. Clin Cancer Res. 2013. PMID: 23536434 Free PMC article.

8

27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.

Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, Howe MK, Carver NJ, Pillai RV, Sullivan PM, Sondhi V, Umetani M, Geradts J, McDonnell DP. Nelson ER, et al. Among authors: wardell se. Science. 2013 Nov 29;342(6162):1094-8. doi: 10.1126/science.1241908. Science. 2013. PMID: 24288332 Free PMC article.

9

Obesity, cholesterol metabolism, and breast cancer pathogenesis.

McDonnell DP, Park S, Goulet MT, Jasper J, Wardell SE, Chang CY, Norris JD, Guyton JR, Nelson ER. McDonnell DP, et al. Among authors: wardell se. Cancer Res. 2014 Sep 15;74(18):4976-82. doi: 10.1158/0008-5472.CAN-14-1756. Epub 2014 Jul 24. Cancer Res. 2014. PMID: 25060521 Free PMC article.

10

From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs).

Wardell SE, Nelson ER, McDonnell DP. Wardell SE, et al. Steroids. 2014 Nov;90:30-8. doi: 10.1016/j.steroids.2014.07.013. Epub 2014 Jul 30. Steroids. 2014. PMID: 25084324 Free PMC article.

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