Czech J - Search Results

1

Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin.

Halland N, Brönstrup M, Czech J, Czechtizky W, Evers A, Follmann M, Kohlmann M, Schiell M, Kurz M, Schreuder HA, Kallus C. Halland N, et al. Among authors: czech j. J Med Chem. 2015 Jun 11;58(11):4839-44. doi: 10.1021/jm501840b. Epub 2015 May 20. J Med Chem. 2015. PMID: 25990761

2

Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).

Schreuder H, Liesum A, Lönze P, Stump H, Hoffmann H, Schiell M, Kurz M, Toti L, Bauer A, Kallus C, Klemke-Jahn C, Czech J, Kramer D, Enke H, Niedermeyer THJ, Morrison V, Kumar V, Brönstrup M. Schreuder H, et al. Among authors: czech j. Sci Rep. 2016 Sep 8;6:32958. doi: 10.1038/srep32958. Sci Rep. 2016. PMID: 27604544 Free PMC article.

3

Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).

Halland N, Czech J, Czechtizky W, Evers A, Follmann M, Kohlmann M, Schreuder HA, Kallus C. Halland N, et al. Among authors: czech j. J Med Chem. 2016 Oct 27;59(20):9567-9573. doi: 10.1021/acs.jmedchem.6b01276. Epub 2016 Oct 17. J Med Chem. 2016. PMID: 27749053

4

Identification of high-affinity P2Y₁₂ antagonists based on a phenylpyrazole glutamic acid piperazine backbone.

Zech G, Hessler G, Evers A, Weiss T, Florian P, Just M, Czech J, Czechtizky W, Görlitzer J, Ruf S, Kohlmann M, Nazaré M. Zech G, et al. Among authors: czech j. J Med Chem. 2012 Oct 25;55(20):8615-29. doi: 10.1021/jm300771j. Epub 2012 Oct 4. J Med Chem. 2012. PMID: 22984835

5

Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography.

Nazaré M, Will DW, Matter H, Schreuder H, Ritter K, Urmann M, Essrich M, Bauer A, Wagner M, Czech J, Lorenz M, Laux V, Wehner V. Nazaré M, et al. Among authors: czech j. J Med Chem. 2005 Jul 14;48(14):4511-25. doi: 10.1021/jm0490540. J Med Chem. 2005. PMID: 15999990

6

Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis.

Halland N, Schmidt F, Weiss T, Li Z, Czech J, Saas J, Ding-Pfennigdorff D, Dreyer MK, Strübing C, Nazare M. Halland N, et al. Among authors: czech j. J Med Chem. 2022 Jan 27;65(2):1567-1584. doi: 10.1021/acs.jmedchem.1c01601. Epub 2021 Dec 21. J Med Chem. 2022. PMID: 34931844

7

Novel factor Xa inhibitors based on a benzoic acid scaffold and incorporating a neutral P1 ligand.

Nazaré M, Matter H, Klingler O, Al-Obeidi F, Schreuder H, Zoller G, Czech J, Lorenz M, Dudda A, Peyman A, Nestler HP, Urmann M, Bauer A, Laux V, Wehner V, Will DW. Nazaré M, et al. Among authors: czech j. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2801-5. doi: 10.1016/j.bmcl.2004.03.059. Bioorg Med Chem Lett. 2004. PMID: 15125936

8

Novel factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of P4 substituents in combination with a neutral P1 ligand.

Nazaré M, Essrich M, Will DW, Matter H, Ritter K, Urmann M, Bauer A, Schreuder H, Czech J, Lorenz M, Laux V, Wehner V. Nazaré M, et al. Among authors: czech j. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4197-201. doi: 10.1016/j.bmcl.2004.06.019. Bioorg Med Chem Lett. 2004. PMID: 15261269

9

Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors.

Halland N, Schmidt F, Weiss T, Saas J, Li Z, Czech J, Dreyer M, Hofmeister A, Mertsch K, Dietz U, Strübing C, Nazare M. Halland N, et al. Among authors: czech j. ACS Med Chem Lett. 2014 Oct 23;6(1):73-8. doi: 10.1021/ml5003376. eCollection 2015 Jan 8. ACS Med Chem Lett. 2014. PMID: 25589934 Free PMC article.

10

Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents.

Nazaré M, Essrich M, Will DW, Matter H, Ritter K, Urmann M, Bauer A, Schreuder H, Dudda A, Czech J, Lorenz M, Laux V, Wehner V. Nazaré M, et al. Among authors: czech j. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4191-5. doi: 10.1016/j.bmcl.2004.06.020. Bioorg Med Chem Lett. 2004. PMID: 15261268

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